Therapeutic targeting of eukaryotic initiation factor (eIF) 4E

被引：9

作者：

Pelletier, Jerry ^{[1
,2
,3
,4
,5
]}

Sonenberg, Nahum ^{[1
,2
,3
]}

机构：

[1] McGill Univ, Dept Biochem, Montreal, PQ, Canada

[2] McGill Univ, Rosalind & Morris Goodman Canc Res Inst, Montreal, PQ, Canada

[3] McGill Univ, Ctr Rech Biol Struct CRBS, Montreal, PQ, Canada

[4] McGill Univ, Dept Oncol, Montreal, PQ, Canada

[5] McGill Univ, McGill Res Ctr Complex Traits, Montreal, PQ, Canada

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2023年 / 51卷 / 01期

基金：

加拿大健康研究院;

关键词：

CAP-BINDING PROTEIN; SMALL-MOLECULE INHIBITION; BREAST-CANCER CELLS; MNK KINASE-ACTIVITY; TRANSLATION INITIATION; DEPENDENT TRANSLATION; GENE AMPLIFICATION; ANTISENSE OLIGONUCLEOTIDE; COMPLEX EIF4F; IN-VITRO;

D O I：

10.1042/BST20220285

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Fundamental studies unraveled the role of eukaryotic initiation factor (eIF) 4E in mRNA translation and its control. Under physiological conditions, regulation of translation by eIF4E is essential to cellular homeostasis. Under stress, gene flow information is parsed by eIF4E to support adaptive mechanisms that favor cell survival. Dysregulated eIF4E activity fuels tumor formation and progression and modulates response to therapy. Thus, there has been heightened interest in understanding eIF4E function in controlling gene expression as well as developing strategies to block its activity to treat disease.

引用

页码：113 / 124

页数：12

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