Epigallocatechin-3-Gallate, an Active Green Tea Component to Support Anti-VEGFA Therapy in Wet Age-Related Macular Degeneration

被引:10
作者
Blasiak, Janusz [1 ]
Chojnacki, Jan [2 ]
Szczepanska, Joanna [3 ]
Fila, Michal [4 ]
Chojnacki, Cezary [2 ]
Kaarniranta, Kai [5 ,6 ]
Pawlowska, Elzbieta [3 ]
机构
[1] Univ Lodz, Fac Biol & Environm Protect, Dept Mol Genet, PL-90236 Lodz, Poland
[2] Med Univ Lodz, Dept Clin Nutr & Gastroenterol Diagnost, PL-90647 Lodz, Poland
[3] Med Univ Lodz, Dept Pediat Dent, PL-92217 Lodz, Poland
[4] Polish Mothers Mem Hosp Res Inst, Dept Dev Neurol & Epileptol, PL-93338 Lodz, Poland
[5] Univ Eastern Finland, Dept Ophthalmol, Kuopio 70210, Finland
[6] Kuopio Univ Hosp, Dept Ophthalmol, Kuopio 70210, Finland
关键词
age-related macular degeneration; AMD; vascular endothelial growth factor; VEGF; anti-VEGF therapy; neovascularization; green tea; epigallocatechin-3-gallate; EGCG; autophagy; ENDOTHELIAL GROWTH-FACTOR; PIGMENT EPITHELIAL-CELLS; (-)-EPIGALLOCATECHIN GALLATE; RETINAL DEGENERATION; CRYSTAL-STRUCTURE; BETA-CAROTENE; RECEPTOR; EXPRESSION; AUTOPHAGY; EGCG;
D O I
10.3390/nu15153358
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Age-related macular degeneration (AMD) is a largely incurable disease and an emerging problem in aging societies. It occurs in two forms, dry and wet (exudative, neovascular), which may cause legal blindness and sight loss. Currently, there is not any effective treatment for dry AMD. Meanwhile, repeated intravitreal injections with antibodies effective against vascular endothelial growth factor A (VEGFA) slow down wet AMD progression but are not free from complications. (-)-Epigallocatechin-3-gallate (EGCG) is an active compound of green tea, which exerts many beneficial effects in the retinal pigment epithelium and the neural retina. It has been reported to downregulate the VEGFA gene by suppressing its activators. The inhibition of mitogen-activated protein kinases 1 and 3 (MAPK1 and MAPK3) may lie behind the antiangiogenic action of EGCG mediated by VEGFA. EGCG exerts protective effects against UV-induced damage to retinal cells and improves dysfunctional autophagy. EGCG may also interact with the mechanistic target rapamycin (MTOR) and unc-51-like autophagy activating kinase (ULK1) to modulate the interplay between autophagy and apoptosis. Several other studies report beneficial effects of EGCG on the retina that may be related to wet AMD. Therefore, controlled clinical trials are needed to verify whether diet supplementation with EGCG or green tea consumption may improve the results of anti-VEGFA therapy in wet AMD.
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页数:17
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