Recent Progress in Noble Metal Based Nanozymes for Bio-detection Application

In comparison with natural enzymes, nanozymes show many advantages such as high stability, ease to mass production and tunable enzymatic properties and possess great potentials for application in detection and biosensing fields. Especially, noble metal based nanozymes usually exhibit superior catalytic activity and stability. The achievements in precisely synthesizing noble metal -based nanomaterials at atomic levels enable investigation of interaction mechanisms between structures and enzymatic performances. In this review, the development of noble metal based nanozymes were sumarized, including noble metal nanocrystals and noble metal based single -atom nanozymes. The preparation strategies, regulation methods of enzymatic properties and underlying mechanisms were mainly discussed. The applications for detection and biosensing were also elucidated. At last, the challenges and prospects of this area were briefly discussed.