Chromones from the Tobacco Derived Fungus Aspergillus versicolor and Their Antiviral Activity

被引：4

作者：

Shen, Si-Yu ^{[1
,2
]}

Xiong, Wen ^{[3
]}

Li, Shan-Shan ^{[1
,2
]}

Liu, Xiao-Shan ^{[1
,2
]}

Li, Yin-Ke ^{[1
,3
]}

Miao, Dong ^{[1
]}

Li, Xue-Mei ^{[3
]}

Wang, Wei-Guang ^{[1
]}

Du, Gang ^{[1
]}

Gong, Da-Ping ^{[2
]}

Hu, Qiu-fen ^{[1
]}

Ma, Xiao-Wei ^{[3
]}

机构：

[1] Yunnan Minzu Univ, Key Lab Nat Prod Synthet Biol Ethn Med, State Ethn Affairs Commiss, Kunming 650031, Peoples R China

[2] Chinese Acad Agr Sci, Tobacco Res Inst, Qingdao 266101, Peoples R China

[3] China Tobacco Yunnan Ind Co Ltd, Yunnan Key Lab Tobacco Chem, Kunming 650231, Peoples R China

来源：

CHEMISTRY OF NATURAL COMPOUNDS | 2023年 / 59卷 / 03期

基金：

中国国家自然科学基金;

关键词：

chromones; endophytic fungus Aspergillus versicolor; tobacco; anti-TMV activities; FERMENTATION PRODUCTS; DERIVATIVES; BUTYROLACTONES; DISCOVERY; STEM;

D O I：

10.1007/s10600-023-04024-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two new chromones, 8-(3-hydroxypropyl)-2-(3-hydroxy-1-oxopropyl)-6-methoxy-4H-chromen-4-one (1), 2-acetyl-8-(3-hydroxypropyl)-6-methoxy-4H-chromen-4-one (2), along with four known ones (3-6) were isolated from the fermentation products of an endophytic fungus Aspergillus versicolor derived from tobacco. Their structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compounds 1 and 2 were evaluated for their anti-tobacco mosaic virus (anti-TMV) activities. The results showed that compounds 1 and 2 exhibited potential anti-TMV activities with inhibition rates of 35.3 and 30.6%, respectively, rates that are close to that of positive control.

引用

页码：462 / 466

页数：5

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