3D-QSAR study on lipophilic antifolates quinazolines

被引：0

作者：

崔智勇

赵维璋

李仁利

机构：

[1] Beijing 100083

[2] Beijing Medical University

[3] China

[4] Department of Medicinal Chemistry

来源：

Progress in Natural Science | 1999年 / 07期

基金：

中国国家自然科学基金;

关键词：

quinazoline; 3D-QSAR; antifolate; CoMFA;

D O I：

暂无

中图分类号：

O621 [有机化学一般性问题];

学科分类号：

070303 ; 081704 ;

摘要：

In the study of antlfolate quinazoline compounds using the method of CoMFA (comparative of molecular field analysis) , the introduction of the physical-chemical constants correlated to the structures of the compounds has been tried lor setting up the CoMFA model. The inhibitory activities of four new compounds have been predicted by the model The observation of the practical activities of two compounds among them shows that the observed activities are close to the predicted ones The reliability of the obtained CoMFA model has been preliminarily tested and verified

引用

页码：37 / 40

页数：4