Influence of gene modified (IL-7, IL-4 and B7) tumor cell vaccines on tumor antigen presentation

被引：0

作者：

Sophie Cayeux

Günther Richter

Gabrielle Noffz

Bernd Drken

Thomas Blankenstein

机构：

[1] Robert-Rssle Klinik

[2] Virchow Klinikum

[3] Medical Faculty of the Humboldt University of Berlin

[4] Lindenberger Weg

[5] Berlin Germany

[6] Max-Delbrck-Center for Molecular Medicine

[7] Robert Rssle Strasse

[8] Berlin

[9] Germany

[10] Berlin GermanyMax-Delbrck-Center for Molecular Medicine

来源：

实验血液学杂志 | 1997年 / 03期

关键词：

IL-7; gene; tumor cell vaccines on tumor antigen presentation; Influence of gene modified; cell;

D O I：

暂无

中图分类号：

R730.3 [肿瘤免疫学与血清学];

学科分类号：

摘要：

<正> We have previously shown that tumor cellsgenetically modified to co-express IL-4 or IL-7 and B7. 1have increased immunogenicity and provided vaccinessuperior to single gene transfectants or tumor cells/adjuvant mixture. Tumor antigens can be presented eitherdirectly by tumor cells or be indirectly represented byhost APC (cross-priming). Here we asked whether B7. 1and IL-7 or IL-4 improved in an additive fashion one

引用

页码：310 / 310

页数：1