Hepatitis C virus relies on lipoproteins for its life cycle

被引：0

作者：

Germana Grassi ^{[1
]}

Giorgia Di Caprio ^{[1
,2
]}

Gian Maria Fimia ^{[1
,3
]}

Giuseppe Ippolito ^{[1
]}

Marco Tripodi ^{[1
,2
]}

Tonino Alonzi ^{[1
]}

机构：

[1] National Institute for Infectious Diseases “L. Spallanzani” IRCCS

[2] Department of Cellular Biotechnologies and Hematology,Pasteur Institute-Cenci Bolognetti Foundation,Sapienza University of Rome

[3] Department of Biological and Environmental Sciences and Technologies (Di STe BA),University of Salento

来源：

World Journal of Gastroenterology | 2016年 / 22卷 / 06期

关键词：

Apolipoproteins; Hepatitis C virus; Lipid metabolism; Lipoproteins; Review;

D O I：

暂无

中图分类号：

R373.21 [];

学科分类号：

100103 ; 100705 ;

摘要：

Hepatitis C virus(HCV) infects over 150 million people worldwide. In most cases, HCV infection becomes chronic causing liver disease ranging from fibrosis to cirrhosis and hepatocellular carcinoma. Viral persistence and pathogenesis are due to the ability of HCV to deregulate specific host processes, mainly lipid metabolism and innate immunity. In particular, HCV exploits the lipoprotein machineries for almost all steps of its life cycle. The aim of this review is to summarize current knowledge concerning the interplay between HCV and lipoprotein metabolism. We discuss the role played by members of lipoproteins in HCV entry, replication and virion production.

引用

页码：1953 / 1965

页数：13

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