Tetrahydroacridine inhibits voltage-dependent Na~+ current in guinea-pig ventricular myocytes

被引：0
|
作者：
Wei WANG
机构：
来源：
ActaPharmacologicaSinica | 2004年 / 09期
关键词：
<Keyword>Alzheimer disease; cholinesterase inhibitors; sodium channels; tetrahydroacridine (tacrine); myocardium; patch-clamp techniques;
D O I：
暂无
中图分类号：
R965 [实验药理学];
学科分类号：
100602 ; 100706 ;
摘要：
AIM: To study the effects of tetrahydroacridine (tacrine) on voltage-gated Na+ channels in cardiac tissues. METHODS: Single ventricular myocytes were enzymatically dissociated from adult guinea-pig heart. Voltage-dependent Na+current was recorded using whole cell voltage-clamp technique. RESULTS: (1) Tacrine reversibly
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页码：36 / 42
页数：7
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