PD-L1表达及其调控在胶质瘤免疫治疗中作用的研究进展

被引：5

作者：

韦俐

蒋敬庭

机构：

[1] 苏州大学附属第三医院肿瘤生物诊疗中心江苏省肿瘤免疫治疗工程技术研究中心苏州大学细胞治疗研究院

来源：

中国肿瘤生物治疗杂志 | 2020年 / 27卷 / 05期

关键词：

免疫检查点; PD-1; PD-L1; 翻译后修饰; 胶质瘤;

D O I：

暂无

中图分类号：

R739.41 [颅内肿瘤及脑肿瘤];

学科分类号：

摘要：

以PD-1/PD-L1轴为靶点的免疫检查点阻断治疗策略已经应用于临床上多种肿瘤的治疗。PD-L1作为表达于肿瘤细胞中的重要免疫调控靶点,可以应用单克隆抗体阻断其介导的免疫抑制作用,从而恢复T细胞对肿瘤细胞的识别和杀伤。但是,PD-L1的表达受多种因素调控,包括基因组水平、翻译后修饰过程以及翻译后CMTM4/6介导的内含体循环调控等。本文就PD-L1蛋白表达的受调控过程及其在胶质瘤免疫治疗中作用的研究进展作一综述。

引用

页码：566 / 570

页数：5

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