The role of microtubule-associated protein 1B in axonal growth and neuronal migration in the central nervous system

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作者
Maoguang YangMinfei WuPeng XiaChunxin WangPeng YanQi GaoJian LiuHaitao WangXingwei DuanXiaoyu Yang Department of OrthopedicsChinaJapan Union HospitalJilin UniversityChangchun Jilin ProvinceChina [130033 ]
机构
关键词
microtubule-associated protein 1B; central nervous system; axonal regeneration; axonal development; axon guidance; neuronal migration;
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中图分类号
R329 [人体组织学];
学科分类号
100101 ;
摘要
In this review,we discuss the role of microtubule-associated protein 1B(MAP1B) and its phosphorylation in axonal development and regeneration in the central nervous system.MAP1B exhibits similar functions during axonal development and regeneration.MAP1B and phosphorylated MAP1B in neurons and axons maintain a dynamic balance between cytoskeletal components,and regulate the stability and interaction of microtubules and actin to promote axonal growth,neural connectivity and regeneration in the central nervous system.
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页码:842 / 848
页数:7
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