Effects of aluminum potassium sulfate on learning,memory,and cholinergic system in mice

被引：1

作者：

伍迎红

周钟鸣

熊玉兰

王彦礼

孙建辉

廖宏标

罗宣德

机构：

[1] 中国中医研究院中药研究所

[2] 国家医药研究开发中心

来源：

ActaPharmacologicaSinica | 1998年 / 06期

关键词：

铝; 铝化合物; AF64A; 氮丙啶; 芥子化合物; 记忆; 回避学习; 乙酰胆碱; 胆碱乙酰基转移酶;

D O I：

暂无

中图分类号：

R-332,R338.5 [];

学科分类号：

1001 ;

摘要：

目的：研究硫酸铝钾中的铝对正常及ＡＦ６４Ａ小鼠学习、记忆的影响．方法：被动回避反射仪测避暗潜伏期（ＳＴＬ）；原子吸收分光光度法测血、脑铝；化学发光法测脑乙酰胆碱（ＡＣｈ）；放射化学法测脑胆碱乙酰基转移酶（ＣｈＡＴ）．结果：１ｇ·ｋｇ－１组３０日时，血脑铝升高；６０日伴ＳＴＬ、ＡＣｈ、ＣｈＡＴ分别下降４６４％，８５％，２２６％；９０日ＳＴＬ、ＡＣｈ、ＣｈＡＴ分别下降５００％，１１１％和２７８％．０２５ｇ·ｋｇ－１只有血铝升高．１ｇ·ｋｇ－１使ＡＦ６４Ａ模型小鼠血、脑铝升高，其他无改变．结论：硫酸铝钾１ｇ·ｋｇ－１·ｄ－１６０日使小鼠学习、记忆障碍及胆碱能系统改变

引用

页码：10 / 13

页数：4

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