Seroepidemiology of hepatitis B virus infection and impact of vaccination

被引：0

作者：

Peng Huang ^{[1
]}

Li-Guo Zhu ^{[2
]}

Ye-Fei Zhu ^{[2
]}

Ming Yue ^{[3
]}

Jing Su ^{[1
]}

Feng-Cai Zhu ^{[2
]}

Hai-Tao Yang ^{[2
]}

Yun Zhang ^{[4
]}

Hong-Bing Shen ^{[1
]}

Rong-Bin Yu ^{[1
]}

Xiang-Jun Zhai ^{[2
]}

Zhi-Hang Peng ^{[1
]}

机构：

[1] Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University

[2] Jiangsu Provincial Centre for Disease Control and Prevention

[3] Department of Infectious Disease, The First Affiliated Hospital of Nanjing Medical University

[4] Department of Epidemiology, Medical Institute of Nanjing Army

来源：

World Journal of Gastroenterology | 2015年 / 21卷 / 25期

关键词：

Epidemiological study; Familial history; Hepatitis B surface antigen; Immunization; General population;

D O I：

暂无

中图分类号：

R512.62 [];

学科分类号：

100401 ;

摘要：

AIM: To investigate hepatitis B virus(HBV) prevalence in the general population in China.METHODS: A total of 148931 individuals were investigated by multistage random sampling in Eastern China. Data were collected on demographics and hepatitis B vaccination history, and serum was tested for hepatitis B surface antigen(HBs Ag) by ELISA. RESULTS: A total of 11469 participants(7.70%, 95%CI: 7.57%-7.84%) were positive for HBs Ag. HBs Ag prevalence was 0.77% among children < 5 years old but increased progressively from adolescents(1.40%-2.55%) to adults(5.69%-11.22%). A decrease in HBs Ag prevalence was strongly associated with vaccination and familial history of HBV among both children and adult groups. Meanwhile, HBs Ag risk in adults was associated with invasive testing and sharing needles. The HBV immunization rate among participants aged < 20 years was 93.30%(95%CI: 93.01%-93.58%). Significant difference in HBs Ag prevalence appeared between vaccinated and unvaccinated participants(3.59% vs 10.22%). CONCLUSION: Although the national goal of HBs Ag prevalence < 1% among children < 5 years old has been reached, immunization programs should be maintained to prevent resurgence.

引用

页码：7842 / 7850

页数：9

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