Brain-derived neurotrophic factor prevents beta-amyloid-induced apoptosis of pheochromocytoma cells by regulating Bax/Bcl-2 expression

被引：0

作者：

Zhikun SunXingrong MaHongqi YangJiahua ZhaoJiewen Zhang Department of NeurologyHenan Provincial Peoples HospitalZhengzhou Henan ProvinceChina Department of Neurologythe First Affiliated HospitalZhengzhou UniversityZhengzhou Henan ProvinceChina ^{[1
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机构：

来源：

Neural Regeneration Research | 2012年 / 7卷 / 05期

关键词：

Alzheimer’s disease; apoptosis; β-amyloid peptide; Bax; brain-derived neurotrophic factor; Bcl-2; tyrosine kinase receptor B;

D O I：

暂无

中图分类号：

R749.16 [];

学科分类号：

100203 ;

摘要：

Brain-derived neurotrophic factor was utilized in the present study to treat cell injury models induced by aggregated β-amyloid(25-35).Methylthiazolyldiphenyl-tetrazolium bromide assay and western blot analysis showed that brain-derived neurotrophic factor provided neuroprotection against cellular apoptosis by suppressing the decline in β-amyloid(25-35)-induced cell activity and the increasing ratio of Bax/Bcl-2.After treating pheochromocytoma cells with tyrosine kinase receptor B receptor inhibitor K252a,brain-derived neurotrophic factor reverses the above-mentioned changes.The experimental findings suggested that brain-derived neurotrophic factor prevented β-amyloid peptide-induced cellular apoptosis by modulating Bax/Bcl-2 expression,and this effect was associated with binding to the specific tyrosine kinase receptor B receptor.

引用

页码：347 / 351

页数：5

共 21 条

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