Genetic and epigenetic changes associated with cholangiocarcinoma:From DNA methylation to microRNAs

被引：7
|
作者：
Monique Stutes
Steven Tran
Sharon DeMorrow
机构：
[1] 76504 United States
[2] 76504 United States Department of Medicine Texas A&M Health Science Center College of Medicine Temple Texas 76504 United States
[3] Department of Medicine Texas A&M Health Science Center College of Medicine Temple Texas
[4] Division of Research and Education Scott and White Hospital Temple Texas
[5] Division of Research and Education Scott and White Hospital Temple Texas
来源：
World Journal of Gastroenterology | 2007年 / 48期
关键词：
Promoter regions; CpG islands; Tumor suppressor; Oncogene; In? ammation;
D O I：
暂无
中图分类号：
R735.8 [胆囊、胆道肿瘤];
学科分类号：
100214 ;
摘要：
Cholangiocarcinomas are malignant epithelial liver tumors arising from the intra- and extra-hepatic bile ducts. Little is known about the molecular development of this disease, and very few effective treatment options are available. Thus, prognosis is poor. Genetic and epigenetic changes play an integral role in the neoplastic transformation of human cells to their malignant counterparts. This review summarizes some of the more prevalent genetic alterations (by microRNA expression) and epigenetic changes (hypermethylation of specific gene promoters) that are thought to contribute to the carcinogenic process in cholangiocarcinoma.
引用
收藏
页码：6465 / 6469
页数：5
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