Association of extraintestinal manifestations of inflammatory bowel disease in a province of western Hungary with disease phenotype:Results of a 25-year follow-up study

AIM:IBD is a systemic disease associated with a largenumber of extraintestinal manifestations (EIMs).Our aimwas to determine the prevalence of EIMs in a large IBDcohort in Veszprem Province in a 25-year follow-up study.METHODS:Eight hundred and seventy-three IBD patientswere enrolled (ulcerative colitis/UC/:619,m/f:317/302,mean age at presentation:38.3 years,average diseaseduration:11.2 years;Crohn’s disease/CD/:254,m/f:125/129,mean age at presentation:32.5 years,average diseaseduration:9.2 years).Intestinal,extraintestinal signs andlaboratory tests were monitored regularly.Any alterationsuggesting an EIMs was investigated by a specialist.RESULTS:A total of 21.3% of patients with IBD had EIM(UC:15.0%,CD:36.6%).Age at presentation did not affectthe likelihood of EIM.Prevalence of EIMs was higher in womenand in CD,ocular complications and primary sclerosingcholangitis (PSC) were more frequent in UC.In UC there wasan increased tendency of EIM in patients with a more extensivedisease.Joint complications were more frequent in CD(22.4% vsUC 10.2%,P<0.01).In UC positive family historyincreased the risk of joint complications (OR:3.63).In CD thefrequency of type-1 peripheral arthritis was increased inpatients with penetrating disease (P=0.028).PSC was presentin 1.6% in UC and 0.8% in CD.Dermatological complicationswere present in 3.8% in UC and 10.2% in CD,the rate ofocular complications was around 3% in both diseases.Rarecomplications were glomerulonephritis,autoimmune hemolyticanaemia and celiac disease.CONCLUSION:Prevalence of EIM in Hungarian IBD patientsis in concordance with data from Western countries.Thehigh number of EIM supports a role for complex follow-upin these patients.