Leptin and peroxisome proliferator-activated receptor γ expression in colorectal adenoma

AIM:To investigate the expressions of leptin and peroxisome proliferator-activated receptor γ(PPARG) in relation to body mass index(BMI).METHODS:We evaluated leptin and PPARG expression in 30 adenomas over 1 cm in size by immunohistochemical staining.In addition,clinicopathologic features including BMI were assessed.RESULTS:PPARG and leptin expression showed a strong positive correlation(P = 0.035).The average BMI of the leptin-positive group was higher than that of the leptin-negative group(25.4 ± 3.4 kg/m 2 vs 22.6 ± 2.4 kg/m 2,P = 0.018),and leptin expression was significantly correlated with high BMI(P = 0.024).Leptinexpression was more frequently observed in intermediate/high grade dysplasia than in low grade dysplasia(P = 0.030).However,PPARG expression was not correlated with BMI and grade of dysplasia.CONCLUSION:BMI has influenced on the leptin expression of colorectal adenoma.The exact mechanism underlies the strong correlation between leptin and PPARG expression needs further study.