Leptin and peroxisome proliferator-activated receptor γ expression in colorectal adenoma

被引：0
作者：
Hyung Hun Kim [1 ]
You Sun Kim [1 ]
Yun Kyung Kang [2 ,3 ]
Jeong Seop Moon [1 ]
机构：
[1] Department of Internal Medicine,Seoul Paik Hospital,Inje University College of Medicine,Seoul 100-032,South Korea
[2] Department of Pathology,Seoul Paik Hospital,Inje University College of Medicine,Seoul 100-032,South Korea Hyung Hun Kim
[3] Department of Internal Medicine,Kosin University College of Medicine,Busan 602-702,South Korea
来源：
World Journal of Gastroenterology | 2012年 / 06期
关键词：
Leptin; Peroxisome proliferator-activated receptor γ; Obesity; Body mass index; Colorectal adenoma;
D O I：
暂无
中图分类号：
R735.3 [肠肿瘤];
学科分类号：
100214 ;
摘要：
AIM:To investigate the expressions of leptin and peroxisome proliferator-activated receptor γ(PPARG) in relation to body mass index(BMI).METHODS:We evaluated leptin and PPARG expression in 30 adenomas over 1 cm in size by immunohistochemical staining.In addition,clinicopathologic features including BMI were assessed.RESULTS:PPARG and leptin expression showed a strong positive correlation(P = 0.035).The average BMI of the leptin-positive group was higher than that of the leptin-negative group(25.4 ± 3.4 kg/m 2 vs 22.6 ± 2.4 kg/m 2,P = 0.018),and leptin expression was significantly correlated with high BMI(P = 0.024).Leptinexpression was more frequently observed in intermediate/high grade dysplasia than in low grade dysplasia(P = 0.030).However,PPARG expression was not correlated with BMI and grade of dysplasia.CONCLUSION:BMI has influenced on the leptin expression of colorectal adenoma.The exact mechanism underlies the strong correlation between leptin and PPARG expression needs further study.
引用
收藏
页码：557 / 562
页数：6
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