Preparation and quality evaluation of vincristine sulfate-loaded PEG-PLGA nanoparticles

被引：0
|
作者：
Tingting GuoHongyuan ZhuWei XieYanqin ZhouNing WangKai QiuChunfang Guo and Yuxiang Chen School of PharmacyCentral South UniversityChangshaHunan PRChinaMerck Sharp Dohme PharmaceuticalsChangshaHunan PRChina [1 ,2 ,1 ,1 ,1 ,1 ,1 ,1 ,1 ,410078 ,2 ,410008 ]
机构：
来源：
中国现代医学杂志 | 2011年 / 21卷 / 06期
关键词：
PEG-PLGA; nanoparticles; vincristine sulfate; preparation; release;
D O I：
暂无
中图分类号：
TB383.1 []; R96 [药理学];
学科分类号：
100602 ; 100706 ;
摘要：
Objective To prepare the PEG-PLGA nanoparticles loaded with vincristine sulfate(VCR-loaded PEG-PLGA-NPs) and evaluate their quality.Methods VCR-loaded PEG-PLGA-NPs were prepared by the double emulsion solvent evaporation method.The main experimental factors,which influenced the physical and chemical properties of the nanoparticles,were investigated and optimized.Results Under optimal conditions,the VCR-loaded PEG-PLGA-NPs had an average diameter of 135.9 nm with narrow size distribution.The encapsulation efficiency was 68.2%,while the drug loading capacity was 8.34%.In vitro,VCR was released from the PEG-PLGA-NPs sustainedly for more than 13 days with the total amount of 81%.Moreover,the VCR-loaded PEG-PLGA-NPs were relatively stable,which was confirmed by the stability testing.Conclusion The VCR-loaded PEG-PLGA-NPs are a promising nano drug with controlled release,which can be applied widely.
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页码：727 / 732
页数：6
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