Tumor pyruvate kinase M2:A promising molecular target of gastrointestinal cancer

被引：2
|
作者：
Chen Guo [1 ]
Guan Li [2 ]
Jianing Hou [2 ]
Xingming Deng [2 ]
Sheng Ao [2 ]
Zhuofei Li [2 ]
Guoqing Lyu [2 ]
机构：
[1] Department of Biology,Southern University of Science and Technology
[2] Department of Gastrointestinal Surgery,Peking University Shenzhen Hospital
来源：
Chinese Journal of Cancer Research | 2018年 / 30卷 / 06期
关键词：
PKM2(pyruvate kinase M2); metabolic reprogramming; gene transcription; gastrointestinal cancer; therapy targets;
D O I：
暂无
中图分类号：
R735 [消化系肿瘤];
学科分类号：
摘要：
Gastrointestinal(GI) cancer is one of the most common causes of cancer-related deaths worldwide.Tumor markers are valuable in detecting post-surgical recurrence or in monitoring response to chemotherapy.Pyruvate kinase isoform M2(PKM2),a glycolytic enzyme catalyzing conversion of phosphoenolpyruvate(PEP) to pyruvate,confers a growth advantage to the tumor cells and enables them to adapt to the tumor microenvironment.In this review,we have summarized current research on the expression and regulation of PKM2 in tumor cells,and its potential role in GI carcinogenesis and progression.Furthermore,we have also discussed the potential of PKM2 as a diagnostic and screening marker,and a therapeutic target in GI cancer.
引用
收藏
页码：669 / 676
页数：8
相关论文
共 50 条
  • [1] Tumor pyruvate kinase M2: A promising molecular target of gastrointestinal cancer
    Guo, Chen
    Li, Guan
    Hou, Jianing
    Deng, Xingming
    Ao, Sheng
    Li, Zhuofei
    Lyu, Guoqing
    CHINESE JOURNAL OF CANCER RESEARCH, 2018, 30 (06) : 669 - 676
  • [2] Pyruvate kinase isozymes M2 and glutaminase might be promising molecular targets for the treatment of gastric cancer
    Yashiro, Masakazu
    Kitayama, Kishu
    CANCER RESEARCH, 2018, 78 (13)
  • [3] Pyruvate kinase isozyme M2 and glutaminase might be promising molecular targets for the treatment of gastric cancer
    Kitayama, Kishu
    Yashiro, Masakazu
    Morisaki, Tamami
    Miki, Yuichiro
    Okuno, Tomohisa
    Kinoshita, Haruhito
    Fukuoka, Tatsunari
    Kasashima, Hiroaki
    Masuda, Go
    Hasegawa, Tsuyoshi
    Sakurai, Katsunobu
    Kubo, Naoshi
    Hirakawa, Kosei
    Ohira, Masaichi
    CANCER SCIENCE, 2017, 108 (12): : 2462 - 2469
  • [4] TUMOR PYRUVATE KINASE M2 AS BIOMARKER OF ESOPHAGEAL CANCER AND GERD
    Gupta, T.
    Chahal, K. S.
    INFLAMMATION RESEARCH, 2011, 60 : 46 - 46
  • [5] TUMOR PYRUVATE KINASE M2 AS BIOMARKER OF ESOPHAGEAL CANCER AND GERD
    Gupta, Tarun
    Sambyal, Vasudha
    ANNALS OF ONCOLOGY, 2011, 22 : v28 - v28
  • [6] TUMOR PYRUVATE KINASE M2 AS BIOMARKER OF ESOPHAGEAL CANCER AND GERD
    Gupta, T.
    ANNALS OF ONCOLOGY, 2010, 21 : 41 - 41
  • [7] Tumor M2 pyruvate kinase: a tumor marker and its clinical application in gastrointestinal malignancy
    Hardt, Philip D.
    Ewald, Nils
    EXPERT REVIEW OF MOLECULAR DIAGNOSTICS, 2008, 8 (05) : 579 - 585
  • [8] TUMOR PYRUVATE KINASE M2 AS BIOMARKER OF ESOPHAGEAL CANCER AND GERD
    Gupta, T.
    Sambyal, V
    ANNALS OF ONCOLOGY, 2010, 21 : 81 - 81
  • [9] TUMOR M2 PYRUVATE KINASE: CLINICAL APPLICATIONS IN GASTRIC CANCER
    Hardt, P. D.
    ANTICANCER RESEARCH, 2008, 28 (5C) : 3307 - 3307
  • [10] Tumor type M2 pyruvate kinase - Can it be of use in gastrointestinal malignancies detection?
    Rogic, D
    Fucek, M
    Hrstic, I
    Matisic, D
    Fressl, G
    CLINICA CHIMICA ACTA, 2005, 355 : S436 - S436
12345