积雪草苷药理作用及其机制的研究进展

被引:28
作者
杨璐
机构
[1] 沈阳市红十字会医院药剂科
关键词
积雪草苷; 药理作用; 作用机制; 研究进展;
D O I
10.13193/j.archtcm.2008.01.217.yangl.084
中图分类号
R285 [中药药理学];
学科分类号
1008 ;
摘要
积雪草苷是传统中药积雪草中主要的活性成分,现代药理学研究证实其具有抗肿瘤、抗静脉机能不全、抗溃疡、促创伤愈合、抗抑郁、以及恢复神经功能等多种药理活性,同时还显现出在心血管、免疫调节、抗炎、抗病毒等方面的药理作用,临床应用表明了确实的疗效。对积雪草苷丰富的药理作用及其作用机制进行综述。
引用
收藏
页码:215 / 218
页数:4
相关论文
共 14 条
[1]   积雪草总苷对实验性抑郁症大鼠血清皮质酮和单胺类神经递质的影响 [J].
陈瑶 ;
韩婷 ;
芮耀诚 ;
殷明 ;
秦路平 ;
郑汉臣 .
中药材, 2005, (06) :492-496
[2]   积雪草甙诱导肿瘤细胞凋亡及增强长春新碱的抗肿瘤作用 [J].
黄云虹 ;
张胜华 ;
甄瑞贤 ;
许先栋 ;
甄永苏 .
癌症, 2004, (12) :1599-1604
[3]   积雪草总苷对小鼠抑郁行为和脑内氨基酸含量的影响 [J].
陈瑶 ;
韩婷 ;
秦路平 ;
芮耀诚 ;
郑汉臣 .
中药材, 2003, (12) :870-873
[4]  
Evaluation of anxiolytic properties of Gotukola – ( Centella asiatica ) extracts and asiaticoside in rat behavioral models[J] . P. Wijeweera,J.T. Arnason,D. Koszycki,Z. Merali.Phytomedicine . 2006 (9)
[5]   Centella asiatica treatment during postnatal period enhances learning and memory in mice [J].
Rao, SB ;
Chetana, M ;
Devi, PU .
PHYSIOLOGY & BEHAVIOR, 2005, 86 (04) :449-457
[6]   Preliminary immunomodulatory activities of methanol extracts of Eclipta alba and Centella asiatica [J].
Jayathirtha, MG ;
Mishra, SH .
PHYTOMEDICINE, 2004, 11 (04) :361-365
[7]   Protective effect of Centella asiatica on antioxidant tissue defense system against adriamycin induced cardiomyopathy in rats [J].
Gnanapragasam, A ;
Ebenezar, KK ;
Sathish, V ;
Govindaraju, P ;
Devaki, T .
LIFE SCIENCES, 2004, 76 (05) :585-597
[8]  
The healing effects of Centella extract and asiaticoside on acetic acid induced gastric ulcers in rats[J] . Chuen Lung Cheng,Jin Sheng Guo,John Luk,Marcel Wing Leung Koo.Life Sciences . 2004 (18)
[9]   Inhibitory effects of Centella asiatica on azoxymethane-induced aberrant crypt focus formation and carcinogenesis in the intestines of F344 rats [J].
Bunpo, P ;
Kataoka, K ;
Arimochi, H ;
Nakayama, H ;
Kuwahara, T ;
Bando, Y ;
Izumi, K ;
Vinitketkumnuen, U ;
Ohnishi, Y .
FOOD AND CHEMICAL TOXICOLOGY, 2004, 42 (12) :1987-1997
[10]  
Cardioprotective activity of Hydrocotyle asiatica L. in ischemia-reperfusion induced myocardial infarction in rats[J] . R.R Pragada,K.K Veeravalli,K.P.R Chowdary,K.V Routhu.Journal of Ethnopharmacology . 2004 (1)