Semaphorin 3A: from growth cone repellent to promoter of neuronal regeneration

被引：1
|
作者：
Bor Luen Tang
机构：
[1] Department of Biochemistry, Yong Loo Lin School of Medicine,National University Health System,Medical Drive
[2] Graduate School for Integrative Sciences and Engineering,National University of Singapore,Medical Drive
来源：
Neural Regeneration Research | 2018年 / 13卷 / 05期
关键词：
from growth cone repellent to promoter of neuronal regeneration; CNS; Semaphorin; 3A;
D O I：
暂无
中图分类号：
R338 [神经生理学];
学科分类号：
0710 ; 071006 ;
摘要：
Highlight Semaphorin 3A is a classically known axonal guidance cue that mediates axonal growth cone repulsion and collapse.Recent works,however,suggest that it may have the apparently diametrically opposite activity of promoting neuronal regeneration.During embryonic development,the axonal guidance cues facilitate the navigation of axonal growth cones towards the targets
引用
收藏
页码：795 / 796
页数：2
相关论文
共 50 条
  • [11] Semaphorin 3A inhibits ERM protein phosphorylation in growth cone filopodia through inactivation of PI3K
    Gallo, Gianluca
    DEVELOPMENTAL NEUROBIOLOGY, 2008, 68 (07) : 926 - 933
  • [12] A Semaphorin 3A Inhibitor Blocks Axonal Chemorepulsion and Enhances Axon Regeneration
    Montolio, Marisol
    Messeguer, Joaquim
    Masip, Isabel
    Guijarro, Patricia
    Gavin, Rosalina
    Antonio del Rio, Jose
    Messeguer, Angel
    Soriano, Eduardo
    CHEMISTRY & BIOLOGY, 2009, 16 (07): : 691 - 701
  • [13] Regeneration of cortical tissue from brain injury by implantation of defined molecular gradient of semaphorin 3A
    Xu, Zhen
    Wang, Wei
    Ren, Yutian
    Zhang, Wenchong
    Fang, Peilin
    Huang, Linfeng
    Wang, Xin
    Shi, Peng
    BIOMATERIALS, 2018, 157 : 125 - 135
  • [14] Novel role of semaphorin 3A in the growth and progression of hepatocellular carcinoma
    Li, Xuedong
    Chen, Qing
    Yin, Dan
    Shi, Shiming
    Yu, Lei
    Zhou, Shaolai
    Chen, Erbao
    Zhou, Zhengjun
    Shi, Yinghong
    Fan, Jia
    Zhou, Jian
    Dai, Zhi
    ONCOLOGY REPORTS, 2017, 37 (06) : 3313 - 3320
  • [15] Axonal regeneration after administration of semaphorin 3A inhibitor into the injured spinal cord
    Kaneko, S
    Iwanami, A
    Nakamura, M
    Miyao, S
    Kishino, A
    Kikuchi, K
    Kimura, T
    Kumagai, K
    Toyama, Y
    Okano, H
    JOURNAL OF NEUROTRAUMA, 2003, 20 (10) : 1133 - 1133
  • [16] Ischemic neurons prevent vascular regeneration of neural tissue by secreting semaphorin 3A
    Joyal, Jean-Sebastien
    Sitaras, Nicholas
    Binet, Francois
    Rivera, Jose Carlos
    Stahl, Andreas
    Zaniolo, Karine
    Shao, Zhuo
    Polosa, Anna
    Zhu, Tang
    Hamel, David
    Djavari, Mikheil
    Kunik, Dario
    Honore, Jean-Claude
    Picard, Emilie
    Zabeida, Alexandra
    Varma, Daya R.
    Hickson, Gilles
    Mancini, Joseph
    Klagsbrun, Michael
    Costantino, Santiago
    Beausejour, Christian
    Lachapelle, Pierre
    Smith, Lois E. H.
    Chemtob, Sylvain
    Sapieha, Przemyslaw
    BLOOD, 2011, 117 (22) : 6024 - 6035
  • [17] Neuronal growth cone responses to collapsin/semaphorin III are regulated by neurotrophin signaling pathways
    Dontchev, VD
    Letourneau, PC
    Luo, YL
    Ng, SD
    MOLECULAR BIOLOGY OF THE CELL, 1999, 10 : 229A - 229A
  • [18] Semaphorin 3A activates the guanosine triphosphatase Rab5 to promote growth cone collapse and organize callosal axon projections
    Wu, Kong-Yan
    He, Miao
    Hou, Qiong-Qiong
    Sheng, Ai-Li
    Yuan, Lei
    Liu, Fei
    Liu, Wen-Wen
    Li, Guangpu
    Jiang, Xing-Yu
    Luo, Zhen-Ge
    SCIENCE SIGNALING, 2014, 7 (340)
  • [19] Disruption of the Cytoskeleton During Semaphorin 3A Induced Growth Cone Collapse Correlates with Differences in Actin Organization and Associated Binding Proteins
    Brown, Jacquelyn A.
    Bridgman, Paul C.
    DEVELOPMENTAL NEUROBIOLOGY, 2009, 69 (10) : 633 - 646
  • [20] Neuronal Semaphorin 3A Forms a Barrier Preventing Retinal Revascularization in Ischemic Proliferative Retinopathies
    Joyal, J. -S.
    Sitaras, N.
    Binet, F.
    Zaniolo, K.
    Honore, J-C.
    Stahl, A.
    Smith, L. E.
    Chemtob, S.
    Sapieha, P.
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2010, 51 (13)
12345