A label-free single photonic quantum well biosensor based on porous silicon for DNA detection

被引：0

作者：

刘荣霞 ^{[1
]}

陈亮亮 ^{[2
]}

张红燕 ^{[1
]}

贾振红 ^{[3
]}

机构：

[1] School of Physical Science and Technology, Xinjiang University

[2] Key Laboratory of Xinjiang Biological Resources and Gene Engineering, College of Life Sciences and Technology,Xinjiang University

[3] College of Information Science and Engineering, Xinjiang University

来源：

Optoelectronics Letters | 2013年 / 9卷 / 03期

关键词：

well; DNA; free;

D O I：

暂无

中图分类号：

TP212.3 [生物传感器、医学传感器];

学科分类号：

080202 ;

摘要：

The single photonic quantum well (PQW) structures are successfully fabricated on p-type silicon wafer by electrochemical etching process, and are used for DNA detection firstly. The red shift of resonance peak is caused by the changing refractive index of PSi layer, which results from coupling of organic molecules into pores. When the porous silicon (PSi) based single PQW biosensors are immersed in complementary deoxyribonucleic acid (DNA) with different concentrations ranging from 0.625 μM to 10.000 μM, a good linear relationship is observed between the red shift of resonance peak and the complementary DNA concentration. Experimental results show that the detection sensitivity of PSi-based single PQW biosensors is 3.04 nm/μM with a detection limit of 32 nM for 16-base pair DNA oligonucleotides.

引用

页码：225 / 228

页数：4