Protective effect of ischemic preconditioning on liver

被引：0

作者：

张燕忠

张柏根

潘仁龙

机构：

来源：

中华创伤杂志(英文版) | 2001年 / 02期

关键词：

Ischemic preconditioning; Liver; Wounds and injuries; Ischemia-reperfusion;

D O I：

暂无

中图分类号：

R657.3 [肝及肝管];

学科分类号：

1002 ; 100210 ;

摘要：

Objective:: To study the protective effect of ischemic preconditioning (IPC) on the hepatic ischemia-reperfusion injury. Methods: The model of rat liver subjected to ischemia/reperfusion (I/R) injury was made. All 24 mice were divided randomly into 3 groups and anesthetized by 2% sodium pentobarbital (30-40 mg/kg). The enzyme activity of AST, ALT, LDH, SOD and the content of LPO were assayed respectively. Specimens were observed under transmission electron microscope. Results: IPC prevented the increase of ALT, AST and LDH in the blood and that of LPO in the tissues (P< 0.05 ), and maintained high level of SOD in the tissues (P< 0.05 ). Conclusions: IPC has protective effect on the liver function.

引用

页码：59 / 61

页数：3

共 5 条

[1]

Protection of rat hippocampus against ischemic neuronal damage by pretreatment with sublethal ischemia. Liu Y,Kato H,Nakata N,et al. Brain Research . 1992

[2]

Preconditioning of the ischemic myocardium involvement of the L-arginine nitric oxide pathway. Vegh A,Szekeres L,Parratt JR. British Journal of Pharmacology . 1992

[3]

A fresh look at reperfusion injury. Piper HM,Garcia DD,Ovize M. Cardiovascular Research . 1998

[4]

Acute ischemia preconditioning protects against skeletal muscle infarction in the pig. Pang CY,Yang RZ,Zhong A,et al. Cardiovascular Research . 1995

[5]

Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Murry CE,Jennings RB,Reamer KA. Circulation . 1986

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