Targeting neuroinflammation after therapeutic hypothermia for perinatal hypoxic-ischemic brain injury

Hypoxic-ischemic encephalopathy(HIE) has an incidence of 1-3 in 1000 term births in highincome countries(Zhou et al.,2020).The standard treatment for these infants is therapeutic hypothermia.Although therapeutic hypothermia significantly reduces the risk of death and disability for infants with HIE,it is still only partially protective as up to 45% of infants still develop disability despite treatment(Zhou et al.,2020).The current therapeutic hypothermia protocol is optimal for widespread use in infants with moderate to severe HIE.However,it is possible that a more tailored approach for individual babies,