Two new C21 steroidal glycosides isolated from Cynanchum komarovii

被引：0

作者：

ZHAO Dan ^{[1
,2
]}

SU Shan-Shan ^{[3
]}

CHEN Shao-Fei ^{[1
,2
]}

LU Xiao-Jie ^{[1
,2
]}

CHEN Gang ^{[1
,2
]}

WANG Yu-Bo ^{[1
,2
,4
]}

SU Guang-Yue ^{[1
,2
]}

PEI Yue-Hu ^{[1
,2
]}

机构：

[1] Key Laboratory of Structure-Based Drug Design & Discovery,Ministry of Education,Shenyang Pharmaceutical University

[2] School of Traditional Chinese Materia Medica,Shenyang Pharmaceutical University

[3] Testing Laboratory,Qinghai Entry Exit Inspection and Quarantine Bureau

[4] School of Pharmacy,Jinzhou Medical University

来源：

Chinese Journal of Natural Medicines | 2018年 / 16卷 / 08期

基金：

中国国家自然科学基金;

关键词：

Cynanchum komarovii; C21 steroidal glycosides; Cytotoxic activity;

D O I：

暂无

中图分类号：

R284.2 [有效成分的分离与提取];

学科分类号：

1008 ;

摘要：

The present study was designed to further investigate the C21steroidal glycosides in Cynanchum plants.Two new steroidal glycosides based on a 13,14:14,15-disecopregnane-type aglycone,komaroside P(1) and komaroside Q(2),together with three known compounds(3-5) were isolated from the whole herbs of Cynanchum komarovii.The aglycones of compounds 1 and 2 were two new disecopregnane.Their structures were elucidated on the basis of 1 D,2 D NMR spectroscopic data and acid hydrolysis.All the compounds(1-5) showed potent inhibitory activities against human leukemia cell lines(HL-60) with IC50 values ranging from 16.6 to 26.3 μmol·L-1,compared to the positive control 5-fluorouracil(6.4 μmol·L-1).

引用

页码：610 / 614

页数：5

共 7 条

[1] 牛心朴子中三个新C21甾体配糖体
王利勤
沈月毛
周露
周俊
[J]. 云南植物研究, 2006, (06) : 679 - 683
[2] Two new 13,14:14,15-disecopregnane-type compounds from the roots of Cynanchum paniculatum[J] . Dan Zhao,Hai-Feng Wang,Gang Chen,Yi-Peng Li,Hui-Ming Hua,Yue-Hu Pei.Journal of Asian Natural Products Research . 2016 (4)
[3] C 21 steroidal glycosides from Cynanchum stauntonii induce apoptosis in HepG2 cells[J] . Zhi-Qi Yin,Shu-Le Yu,Yu-Jian Wei,Lin Ma,Zheng-Feng Wu,Lei Wang,Qing-Wen Zhang,Ming Zhao,Wen-Cai Ye,Chun-Tao Che,Jian Zhang.Steroids . 2015
[4] Chemical constituents from the roots of Cynanchum paniculatum and their cytotoxic activity[J] . Chung Sub Kim,Ju Yeoun Oh,Sang Un Choi,Kang Ro Lee.Carbohydrate Research . 2013
[5] Steroidal glycosides from Cynanchum forrestii Schlechter[J] . Yue Liu,Youcai Hu,Shishan Yu,Guangmiao Fu,Xiangzhong Huang,Lihua Fan.Steroids . 2005 (1)
[6] Five new C 21 steroidal glycosides from Cynanchum komarovii Al.Iljinski[J] . Wang Liqin,Shen Yuemao,Xu Xing,Wei Yuqing,Zhou Jun.Steroids . 2004 (5)
[7] Bioactive constituents of the roots of Cynanchum atratum
Day, SH
Wang, JP
Won, SJ
Lin, CN
[J]. JOURNAL OF NATURAL PRODUCTS, 2001, 64 (05): : 608 - 611

← 1 →