哌嗪化合物作为酶抑制剂的研究进展

被引:18
作者
甘淋玲 [1 ]
卢一卉 [2 ]
周成合 [1 ,2 ]
机构
[1] 西南大学药学院
[2] 西南大学化学化工学院
关键词
哌嗪; 酶抑制剂; PDE5酶抑制剂; 肽脱甲酰基酶抑制剂; 抗糖尿病; 抗肿瘤;
D O I
暂无
中图分类号
R96 [药理学];
学科分类号
100602 ; 100706 ;
摘要
此文综述了哌嗪化合物作为酶抑制剂在抗2型糖尿病、抗真菌、治疗勃起功能障碍、抗肿瘤、治疗阿尔茨海默病、与抗血栓等方面的研究开发情况。
引用
收藏
页码:127 / 131
页数:5
相关论文
共 17 条
[1]   苯并咪唑类酶抑制剂研究进展 [J].
孟江平 ;
卢一卉 ;
海力且木·依不那音 ;
周成合 .
中国生化药物杂志, 2008, 29 (06) :418-421
[2]   作用于细菌蛋白质合成的全合成抗菌剂研究进展附视频 [J].
周伟澄 .
中国医药工业杂志, 2007, (11) :805-813
[3]   磺胺类碳酸酐酶抑制剂研究进展 [J].
宋春泽 ;
周成合 ;
袁勇 .
中国新药杂志, 2007, (18) :1438-1444
[4]   Thiadiazolopiperazinyl ureas as inhibitors of fatty acid amide hydrolase [J].
Keith, John M. ;
Apodaca, Richard ;
Xiao, Wei ;
Seierstad, Mark ;
Pattabiraman, Kanaka ;
Wu, Jiejun ;
Webb, Michael ;
Karbarz, Mark J. ;
Brown, Sean ;
Wilson, Sandy ;
Scott, Brian ;
Tham, Chui-Se ;
Luo, Lin ;
Palmer, James ;
Wennerholm, Michelle ;
Chaplan, Sandra ;
Breitenbucher, J. Guy .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2008, 18 (17) :4838-4843
[5]  
Imidazole piperazines: SAR and development of a potent class of cyclin-dependent kinase inhibitors with a novel binding mode[J] . M. Raymond V. Finlay,David G. Acton,David M. Andrews,Andrew J. Barker,Michael Dennis,Eric Fisher,Mark A. Graham,Clive P. Green,David W. Heaton,Galith Karoutchi,Sarah A. Loddick,Rémy Morgentin,Andrew Roberts,Julie A. Tucker,Hazel M. Weir.Bioorganic & Medicinal Chemistry Letters . 2008 (15)
[6]  
Inhibitory effects of a series of 7-substituted-indazoles toward nitric oxide synthases: Particular potency of 1 H -indazole-7-carbonitrile[J] . Betty Cottyn,Francine Acher,Booma Ramassamy,Luke Alvey,Michel Lepoivre,Yves Frapart,Dennis Stuehr,Daniel Mansuy,Jean-Luc Boucher,Dominique Vichard.Bioorganic & Medicinal Chemistry . 2008 (11)
[7]  
Design, synthesis and molecular docking studies of novel triazole antifungal compounds[J] . Qiu Qin He,Ke Li,Yong Bing Cao,Huan Wen Dong,Li Hua Zhao,Chao Mei Liu,Chun Quan Sheng.Chinese Chemical Letters . 2007 (6)
[8]   Design and synthesis of thiazole-5-hydroxamic acids as novel histone deacetylase inhibitors [J].
Anandan, Sampath-Kumar ;
Ward, John S. ;
Brokx, Richard D. ;
Denny, Trisha ;
Bray, Mark R. ;
Patel, Dinesh V. ;
Xiao, Xiao-Yi .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2007, 17 (21) :5995-5999
[9]   [(S)-γ-(4-Aryl-1-piperazinyl)-L-prolyl]thiazolidines as a novel series of highly potent and long-lasting DPP-IV inhibitors [J].
Yoshida, Tomohiro ;
Sakashita, Hiroshi ;
Akahoshi, Fumihiko ;
Hayashi, Yoshiharu .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2007, 17 (09) :2618-2621
[10]   Synthesis of novel triazole derivatives as inhibitors of cytochrome P450 14α-demethylase (CYP51) [J].
Sun, Qing-Yan ;
Xu, Han-Ming ;
Cao, Yong-Bing ;
Zhang, Wan-Nian ;
Wu, Qiu-Ye ;
Zhang, Da-Zhi ;
Zhang, Jun ;
Zhao, Hui-Qing ;
Jiang, Yaan-Ying .
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2007, 42 (09) :1226-1233