Short-term effect of 0.01% atropine sulphate eye gel on myopia progression in children

被引:3
|
作者
Shi-Yin Pan [1 ,2 ,3 ]
Yang-Zheng Wang [2 ,3 ]
Jun Li [2 ,3 ]
Xue-Hui Zhang [2 ]
Jin Wang [2 ]
Xiu-Ping Zhu [2 ,3 ]
Xiang-Hua Xiao [2 ,3 ]
Jun-Tian Liu [1 ]
机构
[1] Department of Pharmacology,School of Basic Medical Sciences,Xi'an Jiaotong University Health Science Center
[2] Shaanxi Provincial Clinical Research Center for Ophthalmology,Xi'an First Hospital
[3] Shaanxi Key Laboratory of Ophthalmology,Shaanxi Institute of Ophthalmology
关键词
D O I
暂无
中图分类号
R778.11 [];
学科分类号
100212 ;
摘要
AIM: To investigate the effect of 0.01% atropine sulphate eye gel on myopia progression and axial elongation in a 6-month treatment in children.METHODS: Totally 185 children aged 6-12 y with binocular myopia of 3.0 D or less in both eyes were enrolled in this prospective cohort study. The atropine group(n=125) received one drop of 0.01% atropine sulphate eye gel in each eye before bedtime daily. The control group included 60 matched children without drug intervention during the same period. The spherical equivalent and axial length was recorded at baseline and the sixth month of treatment. The efficacy was evaluated by the change of the spherical equivalent and axial length. Adverse events were also recorded.RESULTS: The average spherical equivalent and axial length at baseline were not statistically significant between the atropine group(-1.64±0.80 D, 24.13±0.76 mm) and the control group(-1.59±0.94 D, 24.06±0.77 mm, P>0.05). After 6 mo, there was significantly difference in the spherical equivalent progression between the atropine and the control group(-0.27±0.33 vs-0.60±0.35 D, P<0.001),with a relative reduction of 55.0% in myopia progression. The increase in axial elongation in the atropine group was significantly less than control group(0.19±0.14 vs 0.26±0.14 mm, P<0.001), with a relative reduction of 26.9% in axial length. The 84.4% and 38.4% of the eyes progressed by less than 0.50 D and remained stable in the atropine group, compared with 51.7% and 4.2% in the control group. No adverse events were observed.CONCLUSION: Atropine sulphate eye gel 0.01% can slow down myopia progression and axial elongation in children with a 6-month treatment.
引用
收藏
页码:1122 / 1127
页数:6
相关论文
共 50 条
  • [21] Atropine 0.01% eye drops slow myopia progression: a systematic review and Meta-analysis
    Ying Zhao
    Kai Feng
    Rui-Bao Liu
    Jin-Hua Pan
    Lai-Lin Zhang
    Zhu-Ping Xu
    Xue-Jing Lu
    International Journal of Ophthalmology, 2019, 12 (08) : 1337 - 1343
  • [22] Atropine 0.01% eye drops slow myopia progression: a systematic review and Meta-analysis
    Zhao, Ying
    Feng, Kai
    Liu, Rui-Bao
    Pan, Jin-Hua
    Zhang, Lai-Lin
    Xu, Zhu-Ping
    Lu, Xue-Jing
    INTERNATIONAL JOURNAL OF OPHTHALMOLOGY, 2019, 12 (08) : 1337 - 1343
  • [23] One-Year Results of 0.01% and 0.05% Atropine Eye Drops in Childhood Myopia Progression
    Akdemir, Sibel Coskun
    Akalin, Irfan
    Gunay, Betul Onal
    JOURNAL OF PEDIATRIC OPHTHALMOLOGY & STRABISMUS, 2025,
  • [24] Comparison of the clinical efficacy of orthokeratology and 0.01% atropine for retardation of myopia progression in myopic children
    Zhang, Ju
    Li, Zhenzhen
    Cheng, Zhiwei
    Wang, Ting
    Shi, Weiyun
    CONTACT LENS & ANTERIOR EYE, 2024, 47 (01):
  • [25] The Short-term Effect of Atropine 0.1% on the Axial Length and Choroid of Children Treated for Myopia Progression Prevention, Measured by Optical Coherence Tomography Angiography
    Koulalis, Jannis A.
    Nelis, Pieter
    Cools, Wilfried
    Tezcan, Fatma
    Kuijpers, Robert W.
    JOURNAL OF PEDIATRIC OPHTHALMOLOGY & STRABISMUS, 2025,
  • [26] Effect of 0.01% atropine eye drops combined with different optical treatments to control low myopia in Chinese children
    Cao, Xindan
    Guo, Ziqi
    Wei, Zhiyuan
    Ming, Hongfei
    Ma, Bing
    Zhao, Yue
    Zhang, Yue
    Guo, Lei
    Peng, Cheng
    CONTACT LENS & ANTERIOR EYE, 2025, 48 (01):
  • [27] Short-Term Effects of Atropine 0.01% on the Structure and Vasculature of the Choroid and Retina in Myopic Chinese Children
    Wang, Yuliang
    Zhu, Xingxue
    Xuan, Yi
    Wang, Min
    Zhou, Xingtao
    Qu, Xiaomei
    OPHTHALMOLOGY AND THERAPY, 2022, 11 (02) : 833 - 856
  • [28] Short-Term Effects of Atropine 0.01% on the Structure and Vasculature of the Choroid and Retina in Myopic Chinese Children
    Yuliang Wang
    Xingxue Zhu
    Yi Xuan
    Min Wang
    Xingtao Zhou
    Xiaomei Qu
    Ophthalmology and Therapy, 2022, 11 : 833 - 856
  • [29] A multicenter Spanish study of atropine 0.01% in childhood myopia progression
    Inés Pérez-Flores
    Beatríz Macías-Murelaga
    Jesús Barrio-Barrio
    Scientific Reports, 11
  • [30] Atropine 0.01% Eyedrops Significantly Reduce the Progression of Childhood Myopia
    Clark, Tiana Y.
    Clark, Robert A.
    JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS, 2015, 31 (09) : 541 - 545