Synthesis, Characterization and Antitumor Activity of Lanthanum(Ⅲ) Complex with Demethylcantharidate

被引：5

作者：

尹富玲

邹嘉佳

许玲

王煦

李荣昌

机构：

[1] School of Pharmaceutical Science

[2] China

[3] Beijing 100083

[4] Peking University

[5] Department of Chemical Biology

来源：

Journal of Rare Earths | 2005年 / 05期

关键词：

lanthanum complex; demethylcantharidate group; antitumor activity; rare earths;

D O I：

暂无

中图分类号：

R73-3 [肿瘤学实验研究]; R914.5 [有机合成药物化学];

学科分类号：

100214 ; 100701 ;

摘要：

A novel complex of lanthanum（Ⅲ） with demethylcantharidate group （DCA）, Na[La（DCA）2（H2O）], was synthesized in aqueous solution and characterized by elemental analysis, molar conductance, IR, UV, 1H-NMR spectra and TG-DTA. The results suggest that lanthanum ion is seven-coordinated. Six oxygen atoms are from carboxyl groups and cyclic ethers of two DCA ligand, and on oxygen is from a H2O. The antitumor activities of the complex against HL-60 human leukemia, BGC-823 human gastric carcinoma, Bel-7402 human hepatic carcinoma, Hela human cervical carcinoma were investigated with MTT or SRB assays. Na[La（DCA）2（H2O）] exhibits stronger inhibition against certain kinds of cancer cells than Na2DCA in vitro.

引用

页码：596 / 599

页数：4