云南省首例人感染G4基因型欧亚类禽H1N1猪流感病毒病原学特征分析

被引：20

作者：

李梓 ^{[1
]}

赵晓南 ^{[2
]}

黄维娟 ^{[1
]}

杨磊 ^{[1
]}

成艳辉 ^{[1
]}

谭敏菊 ^{[1
]}

李希妍 ^{[1
]}

刘佳 ^{[1
]}

陈志肖 ^{[1
]}

隗合江 ^{[1
]}

伏晓庆 ^{[2
]}

王大燕 ^{[1
]}

机构：

[1] 中国疾病预防控制中心病毒病预防控制所国家流感中心

[2] 云南省疾病预防控制中心

来源：

病毒学报 | 2022年 / 38卷 / 02期

关键词：

欧亚类禽H1N1猪流感病毒(EA H1N1); 氨基酸位点; 耐药性; 受体; 抗体;

D O I：

10.13242/j.cnki.bingduxuebao.004028

中图分类号：

R373.13 [];

学科分类号：

100103 ; 100705 ;

摘要：

2020年云南发现了首例人感染G4基因型欧亚类禽H1N1(EA H1N1)猪流感病毒，针对分离到的A/YunnanMengzi/1462/2020(H1N1v)病毒分析其血凝素（HA）和神经氨酸酶（NA）氨基酸变异位点、生物学耐药、受体亲和力及抗原性变异特征，并对2020-2021年度季节性流感疫苗对该病毒的交叉保护效果进行评价。结果显示，EA H1N1猪流感病毒A/Yunnan-Mengzi/1462/2020(H1N1v)与世界卫生组织推荐的疫苗株A/Hunan/42443/2015(H1N1v)HA和NA氨基酸位点同源性分别为97.9%和97.4%;A/Yunnan-Mengzi/1462/2020(H1N1v)病毒对神经氨酸酶抑制剂敏感，以结合人流感病毒唾液酸受体α2,6为主，与疫苗株抗原性存在8倍以上差异。接种季节性流感疫苗的儿童、成人和老年组人群针对季节性流感疫苗株A/Guangdong-Maonan/SWL1536/2019(H1N1pdm)抗体滴度≥40者占比分别为80.0%、76.7%和63.3%；而对A/Yunnan-Mengzi/1462/2020(H1N1v)抗体滴度仅为13.3%、26.7%和6.7%。本研究提示接种季节性流感疫苗后产生的抗体对G4基因型EA H1N1病毒不能提供有效保护，该病毒与目前EA H1N1病毒疫苗株在氨基酸位点和抗原性上存在显著差异，并且保持了结合人流感病毒唾液酸受体的特性，研究结果提示需要构建新的疫苗株。

引用

页码：290 / 297

页数：8

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