Resistance to verapamil of a multidrug-resistant HL-60/VRPcell line

被引：0
|
作者：
周卫东
张鸿卿
方敏
何琪扬
薛绍白
机构：
[1] China
[2] Department of Biology
[3] Beijing Normal University
[4] Beijing 100875
来源：
Chinese Science Bulletin | 1996年 / 12期
基金：
中国国家自然科学基金;
关键词：
flow cytometry; multidrug resistance; dot blot; hybridization; protein kinase C; protein phosphorylation;
D O I：
暂无
中图分类号：
R73-36 [治疗实验];
学科分类号：
100214 ;
摘要：
Drug resistance of caner cells is one of the main obstacles in cancer chemotherapy andits mechanism is very complex.The cross resistance to many unrelated antitumor drugsappears when the mammal tumor cells are induced by only one drug.The main charactersof this multiple drug resistance are the overexpression of 150—170ku glycoprotein(P-gp)inthe cell membrane.P-gp pumps out the tumor drugs entering the cells by using the energy
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收藏
页码：1033 / 1037
页数：5
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