Loss of interstitial cells of Cajal network in severe idiopathic gastroparesis

被引：1
|
作者：
Edda Battaglia
Gabrio Bassotti
Graziella Bellone
Luca Dughera
Anna Maria Serra
Luigi Chiusa
Alessandro Repici
Pierroberto Mioli
Giorgio Emanuelli
机构：
[1] Department of Biomedical Sciences and Human Oncology University of Torino Italy
[2] Department of Emergency Surgical Unit San Giovanni Battista Hospital Torino Italy
[3] Department of Gastroenterology and Clinical Nutrition University of Torino Italy
[4] Department of Gastroenterology and Clinical Nutrition University of Torino Italy
[5] Gastroenterology Section Department of Clinical and Experimental Medicine University of Perugia Italy
来源：
World Journal of Gastroenterology | 2006年 / 38期
关键词：
C-kit; Gastroparesis; Interstitial cells of Cajal; Stem cell factor;
D O I：
暂无
中图分类号：
R656.6 [胃、十二指肠];
学科分类号：
1002 ; 100210 ;
摘要：
AIM: To report a case of severe idiopathic gastroparesis in complete absence of Kit-positive gastric interstitial cells of Cajal (ICC). METHODS: Gastric tissue from a patient with severe idiopathic gastroparesis unresponsive to medical treatment and requiring surgery was analyzed by conventional histology and immunohistochemistry. RESULTS: Gastric pacemaker cells expressing Kit receptor had completely disappeared while the local level of stem cell factor, the essential ligand for its development and maintenance, was increased. No signs of cell death were observed in the pacemaker region. CONCLUSION: These results are consistent with the hypothesis that a lack of Kit expression may lead to impaired functioning of ICC. Total gastrectomy proves to be curative.
引用
收藏
页码：6172 / 6177
页数：6
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