A general and efficient Lewis acid catalysed Mukaiyama-aldol reaction of difluoroenoxysilanes and ketones

被引：0

作者：

Fu-Min Liao ^{[1
]}

Xiao-Tong Gao ^{[1
]}

Xiao-Si Hu ^{[1
]}

Shi-Liang Xie ^{[1
]}

Jian Zhou ^{[1
,2
,3
]}

机构：

[1] Shanghai Key Laboratory of Green Chemistry and Chemical Processes,School of Chemistry and Molecular Engineering,East China Normal University

[2] State Key Laboratory of Elemento-organic Chemistry,Nankai University

[3] Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development,School of Chemistry and Chemical Engineering,East China Normal University

来源：

Science Bulletin | 2017年 / 62卷 / 22期

基金：

中国国家自然科学基金;

关键词：

Lewis acid catalysed; Mukaiyama-aldol reaction; Ketones; Difluoroenoxysilanes; β-Hydroxy; α; α-difluoro ketones;

D O I：

暂无

中图分类号：

O621.251 [];

学科分类号：

摘要：

We report a general and highly efficient Mukaiyama-aldol reaction of ketones and difluoroenoxysilanes.While the reaction of aryl ketones worked efficiently in the presence of Bi(OTf)3, that of aliphatic ketones required the use of Sc(OTf)3. In addition, Sc(OTf)3was capable of achieving excellent 1,2-selectivity in the corresponding reaction of α,β-unsaturated ketones. This method provides a facile access to differently substituted β-hydroxy α,α-difluoro ketones, versatile synthons for difluomethylated tertiary alcohols.

引用

页码：1504 / 1509

页数：6

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