Effects of quercetin on hepatocyte stimulating factor production by mouse peritoneal macrophages

被引：0

作者：

周斌

张俊平

刘宏

殷明

钱定华

机构：

[1] Department of Stomatology

[2] Changhai Hospital

[3] China

[4] Department of Pharmacology

[5] School of Pharmacy

[6] Shanghai 200433

[7] Second Military Medical University

来源：

Journal of Medical Colleges of PLA | 2003年 / 02期

基金：

中国国家自然科学基金;

关键词：

quercetin; hepatocyte stimulating factor; fibrinogen; interleukin-6; peritoneal macrophage;

D O I：

暂无

中图分类号：

R965 [实验药理学];

学科分类号：

100602 ; 100706 ;

摘要：

Objective: To study the effects of quercetin on hepatocyte stimulating factor production from mouse perito-neal macrophages. Methods: Hepatocyte stimulating factor was evaluated by the amount of fibrinogen synthesized inHep3B cells. Interleukin-6 activity was measured by B9 cell proliferation methyl thiazolyl tetrazolium colorimetric meth-od. Hep3B cell supernatant fibrinogen was quantitated with ELISA. Results: LPS induced the synthesis of hepatocytestimulating factor in mouse peritoneal macrophages, and hepatocyte stimulating factor promotes the synthesis of fibrino-gen from Hep3B cells. Quercetin(5 to 40 μmol/L) inhibited the synthesis of hepatocyte stimulating factor stimulated

引用

页码：121 / 123

页数：3