Alpha-fetoprotein specific CD4 and CD8 T cell responses in patients with hepatocellular carcinoma

被引：0

作者：

Shahriar Behboudi ^{[1
]}

Stephen P Pereira ^{[1
]}

机构：

[1] UCL Institute of Hepatology,University College London,Royal Free Hospitals

来源：

World Journal of Hepatology | 2010年 / 2卷 / 07期

关键词：

Hepatocellular carcinoma; Alpha-fetoprotein; Cell-mediated immunity; Immunotherapy;

D O I：

暂无

中图分类号：

R735.7 [肝肿瘤];

学科分类号：

100214 ;

摘要：

The presence of CD8 T cell responses to tumor associated antigens have been reported in patients with different malignancies. However, there is very little inf ormation on a comparable CD8 and CD4 T cell response to a tumor antigen in liver cancer patients. Here, we re-examine the kinetic and the pattern of T helper 1 and cytotoxic T lymphocyte responses to alpha-fetoprotein (AFP),a tumor rejection antigen in hepatocellular carcinoma (HCC). Then, we discuss the possibility of using AFP-based immunotherapy in combination with necrotizing treatments in HCC patients.

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收藏

页码：256 / 260

页数：5

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