Bioactive glass nanotube scaffold with well-ordered mesoporous structure for improved bioactivity and controlled drug delivery

被引:0
|
作者
Jian Xiao [1 ]
Yizao Wan [1 ,2 ]
Zhiwei Yang [2 ]
Yuan Huang [1 ]
Fanglian Yao [3 ]
Honglin Luo [1 ,2 ]
机构
[1] School of Materials Science and Engineering, Tianjin University
[2] Institute of Advanced Materials, School of Materials Science and Engineering, East China Jiaotong University
[3] Key Laboratory of Systems Bioengineering of Ministry of Education, School of Chemical Engineering and Technology, Tianjin University
基金
中国国家自然科学基金;
关键词
Bioactive glass; Mesopore; Nanotube; Bioactivity; Drug delivery;
D O I
暂无
中图分类号
TQ460.1 [基础理论];
学科分类号
1007 ;
摘要
In this study, a novel mesoporous bioactive glass nanotube(MBGN) scaffold has been fabricated via template-assisted sol-gel method using bacterial cellulose(BC) as template and nonionic block copolymer(P123) as pore-directing agent. The scaffold was characterized by scanning electron microscopy(SEM), transmission electron microscopy(TEM), Fourier-transform infrared(FTIR) spectroscopy, and N;adsorption-desorption analysis. Furthermore, simvastatin was used to evaluate the loading efficiency and release kinetics of the scaffold. The obtained scaffold displays nanofiber-like morphology, ordered mesopores on the tube walls, and interconnected three-dimensional(3 D) network structure that completely replicates the BC template. In addition, it shows dual pore sizes(16.2 and 3.3 nm), large specific surface area(537.2 m;g;) and pore volume(1.429 cm;g;). More importantly, the scaffold possesses excellent apatite-forming ability and sustainable drug release as compared to the counterpart scaffold without mesopores. This unique scaffold can be considered a promising candidate for drug delivery and bone tissue regeneration.
引用
收藏
页码:1959 / 1965
页数:7
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