Animal models of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis

被引：3
作者：
Yoshihisa Takahashi [1 ]
Yurie Soejima [1 ]
Toshio Fukusato [1 ]
机构：
[1] Department of Pathology,Teikyo University School of Medicine,Tokyo 173-8605,Japan
来源：
World Journal of Gastroenterology | 2012年 / 19期
关键词：
Animal model; Nonalcoholic fatty liver disease; Nonalcoholic steatohepatitis; Metabolic syndrome; Histopathology;
D O I：
暂无
中图分类号：
R575.5 [肝代谢障碍];
学科分类号：
1002 ; 100201 ;
摘要：
Nonalcoholic fatty liver disease(NAFLD) is a condition in which excess fat accumulates in the liver of a patient without a history of alcohol abuse.Nonalcoholic steatohepatitis(NASH),a severe form of NAFLD,can progress to liver cirrhosis and hepatocellular carcinoma.NAFLD is regarded as a hepatic manifestation of metabolic syndrome and incidence has been increasing worldwide in line with the increased prevalence of obesity,type 2 diabetes,and hyperlipemia.Animal models of NAFLD/NASH give crucial information,not only in elucidating pathogenesis of NAFLD/NASH but also in examining therapeutic effects of various agents.An ideal model of NAFLD/NASH should correctly reflect both hepatic histopathology and pathophysiology of human NAFLD/NASH.Animal models of NAFLD/NASH are divided into genetic,dietary,and combination models.In this paper,we review commonly used animal models of NAFLD/NASH referring to their advantages and disadvantages.
引用
收藏
页码：2300 / 2308
页数：9
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