Polypeptide dendrimers: Self-assembly and drug delivery

被引：0

作者：

XU XiangHui

LI CaiXia

LI HaiPing

LIU Rong

JIANG Chao

WU Yao

HE Bin* & GU ZhongWei* National Engineering Research Center for Biomaterials

Sichuan University

Chengdu 610064

China

机构：

来源：

Science China(Chemistry) | 2011年 / 02期

关键词：

self-assembly; dendritic polypeptide block copolymer; drug delivery;

D O I：

暂无

中图分类号：

TQ460.1 [基础理论];

学科分类号：

1007 ;

摘要：

Amphiphilic dendritic poly(glutamic acid)-b-polyphenylalanine copolymers were synthesized using generation 3 dendritic poly(glutamic acid) as the macroinitiator in the ring-opening polymerization of NCA-Phe.The block copolymers self-assembled micelles with polyphenylalanine segments as core and dendritic poly(glutamic acid) segments as shell.The biocompatibility of the micelles was studied.The release of the anticancer drug doxorubicin from the micelles was investigated in vitro.The results showed that the sustaining release of the drug could last for 60 h.The micellar drug release system was efficient in inhibiting the proliferation of HepG2 liver cancer cells,75% cancer cells were killed under appropriate in vitro incubation.

引用

页码：326 / 333

页数：8

共 10 条

[1]

New-generation biomedical materials:Peptide dendrimers and their application in biomedicine[J]. GU ZhongWei,LUO Kui,SHE WenChuan,WU Yao & HE Bin National Engineering Research Center for Biomaterials,Sichuan University,Chengdu 610064,China.Science China(Chemistry). 2010(03)

[2] Self-Assembly of Peptide-Inorganic Hybrid Spheres for Adaptive Encapsulation of Guests [J].

Yan, Xuehai ;

Zhu, Pengli ;

Fei, Jinbo ;

Li, Junbai .

ADVANCED MATERIALS, 2010, 22 (11) :1283-+

[3] Exploiting Biocatalysis in Peptide Self-Assembly [J].

Williams, Richard J. ;

Mart, Robert J. ;

Ulijn, Rein V. .

BIOPOLYMERS, 2010, 94 (01) :107-117

[4] A paradigm for peptide vaccine delivery using viral epitopes encapsulated in degradable polymer hydrogel capsules [J].

Chong, Siow-Feng ;

Sexton, Amy ;

De Rose, Robert ;

Kent, Stephen J. ;

Zelikin, Alexander N. ;

Caruso, Frank .

BIOMATERIALS, 2009, 30 (28) :5178-5186

[5] Self-assembled oligopeptide nanostructures for co-delivery of drug and gene with synergistic therapeutic effect [J].

Wiradharma, Nikken ;

Tong, Yen Wah ;

Yang, Yi-Yan .

BIOMATERIALS, 2009, 30 (17) :3100-3109

[6] Construction of nanoscale protein particle using temperature-sensitive elastin-like peptide and polyaspartic acid chain [J].

Fujita, Yoshihiko ;

Mie, Masayasu ;

Kobatake, Eiry .

BIOMATERIALS, 2009, 30 (20) :3450-3457

[7] Biocompatibility of amphiphilic diblock copolypeptide hydrogels in the central nervous system [J].

Yang, Chu-Ya ;

Song, Bingbing ;

Ao, Yan ;

Nowak, Andrew P. ;

Abelowitz, Ryan B. ;

Korsak, Rose A. ;

Havton, Leif A. ;

Deming, Timothy J. ;

Sofroniew, Michael V. .

BIOMATERIALS, 2009, 30 (15) :2881-2898

[8] Self-assembled peptide-based hydrogels as scaffolds for anchorage-dependent cells [J].

Zhou, Mi ;

Smith, Andrew M. ;

Das, Apurba K. ;

Hodson, Nigel W. ;

Collins, Richard F. ;

Ulijn, Rein V. ;

Gough, Julie E. .

BIOMATERIALS, 2009, 30 (13) :2523-2530

[9]

Poly( l -histidine)–PEG block copolymer micelles and pH-induced destabilization[J] . Eun Seong Lee,Hyun Joon Shin,Kun Na,You Han Bae.Journal of Controlled Release . 2003 (3)

[10]

Macromolecular diffusion and release from self-assembled P-hairpin peptide hydrogels .2 Branco M.C,Pochan D.J,Wagner N.J,Schneider J.R. Biomaterials . 2009

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