Synthesis,Crystal Structure and Biological Activity of 2-(1-(3-Bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carbonyl)piperidin-4-yl)-N-isopropyl-1,3-thiazole-4-carboxamide

被引：8

作者：

LI Feng-Yun

ZHU Yu-Jiea

FAN Zhi-Jin

XU Jing-Hua

GUO Xiao-Feng

ZONG Guang-Ning

SONG Hai-Bin

CHEN Lai

SONG Yin-Qi

QIAN Xiao-Lin

MA Liu-Yong

WANG Jia-Ran

机构：

[1] StateKeyLaboratoryofElemento-OrganicChemistry,CollaborativeInnovationCenterofChemicalScienceandEngineering(Tianjin),NankaiUniversity

来源：

结构化学 | 2015年 / 34卷 / 05期

关键词：

pyrazole; thiazole; crystal structure; biological activity;

D O I：

10.14102/j.cnki.0254-5861.2011-0609

中图分类号：

O626 [杂环化合物];

学科分类号：

070303 ; 081704 ;

摘要：

The title compound 2-(1-(3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carbonyl)piperidin-4-yl)-N-isopropylthiazole-4-carboxamide(C21H22Br Cl N6O2 S,Mr = 536.04) has been synthesized,and its structure was characterized by IR spectra,1H-NMR,13C-NMR,EA,and single-crystal X-ray diffraction.The crystal of the title compound belongs to monoclinic system,space group P/c with a = 15.146(3),b = 11.573(2),c = 26.937(5) ?,β = 103.64(3)°,V = 1839.0(6) ?3,Z = 4,Dc = 1.557 g/cm3,μ(Mo Ka) = 0.71073 mm-1,F(000) = 2192,R = 0.0601 and w R = 0.1392.There exist one intramolecular hydrogen bond at N–H···N and four intermolecular weak interactions at O(2)···H(1),Cl(1)···H(12),O(1)···Cl(1) and S(1)···O(2).Bioassay results indicated that the title compound had good fungicidal and antiviral activities against tobacco mosaic virus.

引用

页码：659 / 666

页数：8

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