Diterpenoids from the aerial parts of Leonurus macranthus

被引：0

作者：

Yunfang Zhao ^{[1
]}

Zheng Huang ^{[1
]}

Jing Sun ^{[1
]}

Daoran Pang ^{[1
]}

Xiaonan Chen ^{[1
]}

Huina Yao ^{[1
]}

Zhixiang Zhu ^{[1
]}

Jiao Zheng ^{[1
]}

Pengfei Tu ^{[1
]}

Jun Li ^{[1
]}

机构：

[1] Modern Research Center for Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese Medicine

来源：

Chinese Chemical Letters | 2019年 / 30卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Lamiaceae; Labdane diterpenoid; cis-Clerodane diterpenoid; Anti-neuroinflammation;

D O I：

暂无

中图分类号：

TQ464.2 [萜类及其衍生物];

学科分类号：

100705 ;

摘要：

Four new diterpenoids including one cis clerodane-type（1） and three highly oxygenated labdane-type diterpenes（2–4） were isolated from the aerial parts of Leonurus macranthus. Their structures were elucidated on the basis of spectroscopic data（NMR, UV, IR, and MS）. Compound 1 represents the first example of cis clerodane-type diterpene in the plants of Leonurus genus. Compounds 1 and 4 exhibited weak inhibition of nitric oxide production in lipopolysaccharide-stimulated BV-2 microglial cells with IC;values of 35.8 ± 3.6 mmol/L and 48.6 ± 4.8 mmol/L, respectively

引用

页码：47 / 50

页数：4

共 50 条

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