Diabetic nephropathy(DN)is the most common microvascular complication of diabetes and is one of the major causes of end-stage renal disease(ESRD).Cilostazol,an antiplatelet drug,plays an important role in the prevention and treatment of the chronic complications of diabetes through a series of mechanisms,including anti-inflammation,the inhibition of vascular smooth muscle proliferation,the protection of nerve cells,and the regulation of blood lipids.In this study,we observed the effects of cilostazol on serum soluble cell adhesion molecule-1(sICAM-1)and monocyte