Synthesis and pharmacological activity evaluation of curcumin derivatives

被引：0
|
作者：
Jaggi Lal [1 ,2 ]
Sushil K.Gupta [1 ]
D.Thavaselvam [3 ]
Dau D.Agarwal [1 ]
机构：
[1] School of Studies in Chemistry, Jiwaji University
[2] Department of Chemistry, Dr. K.N. Modi University  3. Microbiology Division, Defence Research Development Establishment
来源：
ChineseChemicalLetters | 2016年 / 27卷 / 07期
关键词：
Curcumin dihydropyrimidinones/thiones/; imines; Microwave irradiations; Antioxidant capacity; Anti-inflammatory activity;
D O I：
暂无
中图分类号：
R284 [中药化学];
学科分类号：
1008 ;
摘要：
Curcumin 3,4-dihydropyrimidinones/thiones/imines have been synthesized using one-pot cyclocondensation of curcumin with substituted aromatic aldehydes and urea/thiourea/guanidine in the presence of chitosamine hydrochloride as a biodegradable and nontoxic catalyst under solvent-free microwave irradiation.The synthesized product was purified by crystallization from ethanol and the process does not involve any hazardous solvent.All the synthesized curcumin derivatives 4a-o were screened for antioxidant and anti-inflammatory activity.Biological activity data of the synthesized showed that most of the synthesized compounds exhibited greater antioxidant and anti-inflammatory activity than curcumin.
引用
收藏
页码：1067 / 1072
页数：6
相关论文
共 50 条
  • [1] Synthesis and pharmacological activity evaluation of curcumin derivatives
    Lal, Jaggi
    Gupta, Sushil K.
    Thavaselvam, D.
    Agarwal, Dau D.
    CHINESE CHEMICAL LETTERS, 2016, 27 (07) : 1067 - 1072
  • [2] SYNTHESIS AND EVALUATION OF ANTIMALARIAL ACTIVITY OF CURCUMIN DERIVATIVES
    Gomes, Patricia Ramos
    Miguel, Fabio Balbino
    de Oliveira, Michael Eder
    Ferreira, Vanessa Viana
    Martins Guimaraes, Daniel Silqueira
    de Lima, Aline Brito
    Barbosa, Camila de Souza
    de Oliveira, Mariana Amorim
    de Almeida, Mauro Vieira
    Ribeiro Viana, Gustavo Henrique
    Costa Couri, Mara Rubia
    Varotti, Fernando de Pilla
    QUIMICA NOVA, 2014, 37 (03): : 492 - 496
  • [3] Synthesis and Pharmacological Activity of 4', 4"- bit Modified Curcumin Derivatives
    Tan, Yan
    Lang, Jiajia
    Tang, Meilun
    Mi, Pengbing
    Zheng, Xing
    LETTERS IN DRUG DESIGN & DISCOVERY, 2023, 20 (12) : 1884 - 1897
  • [4] Synthesis and pharmacological activity evaluation of arctigenin monoester derivatives
    Chen, Qiulian
    Yang, Limin
    Han, Mei
    Cai, Enbo
    Zhao, Yan
    BIOMEDICINE & PHARMACOTHERAPY, 2016, 84 : 1792 - 1801
  • [5] Promising Anticancer Activity of β-Carboline Derivatives: Design, Synthesis, and Pharmacological Evaluation
    Chourasiya, Ravindra Kumar
    Agrawal, Ram Kishore
    Vaidya, Ankur
    CHEMISTRY-SWITZERLAND, 2022, 4 (04): : 1395 - 1406
  • [6] Synthesis and pharmacological activity of phenethylamide derivatives
    L. V. Anikina
    Yu. B. Vikharev
    M. A. El’tsov
    Yu. V. Shklyaev
    Pharmaceutical Chemistry Journal, 2009, 43 : 495 - 497
  • [7] Synthesis and pharmacological activity of hydroacridines and their derivatives
    Nikolaeva T.G.
    Petrova N.V.
    Safonova A.A.
    Kulikova L.K.
    Kriven'ko A.P.
    Pharmaceutical Chemistry Journal, 1998, 32 (3) : 136 - 138
  • [8] SYNTHESIS AND PHARMACOLOGICAL ACTIVITY OF TETRAHYDRODIBENZOFURANOLS DERIVATIVES
    BORISOVA, LN
    ZHMURENKO, LA
    GLOZMAN, OM
    CHERNYAKOVA, IV
    EKIMOVA, OV
    LEZINA, VP
    TROITSKAYA, VS
    ZHUKOV, VN
    SMIRNOV, LD
    KHIMIKO-FARMATSEVTICHESKII ZHURNAL, 1988, 22 (10): : 1207 - 1212
  • [9] SYNTHESIS AND PHARMACOLOGICAL ACTIVITY OF PHENETHYLAMIDE DERIVATIVES
    Anikina, L. V.
    Vikharev, Yu. B.
    El'tsov, M. A.
    Shklyaev, Yu. V.
    PHARMACEUTICAL CHEMISTRY JOURNAL, 2009, 43 (09) : 495 - 497
  • [10] Synthesis and pharmacological activity of benzodipyran derivatives
    Hishmat, OH
    ElDiwani, HI
    Melek, FR
    ElSahrawi, HM
    ElShabrawi, O
    INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 1996, 35 (01): : 30 - 35
12345