Synthesis and Characterization of Surface-modified Fe3O4 Super-paramagnetic Nanoparticles

被引：0
|
作者：
张占洁 [1 ]
马佳 [1 ]
徐双兵 [1 ]
任精华 [1 ]
秦铀 [1 ]
黄晶 [1 ]
杨坤禹 [1 ]
张志平 [2 ]
伍钢 [1 ]
机构：
[1] Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
[2] School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology
来源：
Current Medical Science | 2014年 / 02期
基金：
中国国家自然科学基金;
关键词：
Fe3O4 super-paramagnetic nanoparticles; surface modification; biocompatibility;
D O I：
暂无
中图分类号：
R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
Aqueous dispersion and stability of Fe3O4 nanoparticles remain an issue unresolved since aggregation of naked iron nanoparticles in water. In this study, we successfully synthesized different Fe3O4 super-paramagnetic nanoparticles which were modified by three kinds of materials [DSPE-MPEG2000, TiO2 and poly acrylic acid(PAA)] and further detected their characteristics. Transmission electron microscopy(TEM) clearly showed sizes and morphology of the four kinds of nanoparticles. X-ray diffraction(XRD) proved successfully coating of the three kinds of nanoparticles and their structures were maintained. Vibrating sample magnetometer(VSM) verified that their magnetic properties fitted for the super-paramagnetic function. More importantly, the particle size analysis indicated that Fe3O4@PAA had a better size distribution, biocompatibility, stability and dispersion than the other two kinds of nanoparticles. In addition, using CNE2 cells as a model, we found that all nanoparticles were nontoxic. Taken together, our data suggest that Fe3O4@PAA nanoaparticles are superior in the application of biomedical field among the four kinds of Fe3O4 nanoparticles in the future.
引用
收藏
页码：270 / 275
页数：6
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