Self-assembly of amphiphilic peptides to construct activatable nanophotosensitizers for theranostic photodynamic therapy

被引：3

作者：

Shuang Chen ^{[1
]}

Yongzhuo Liu ^{[2
]}

Ri Liang ^{[1
]}

Gaobo Hong ^{[1
]}

Jing An ^{[1
]}

Xiaojun Peng ^{[1
]}

Wen-Heng Zheng ^{[3
]}

Fengling Song ^{[1
,4
]}

机构：

[1] State Key Laboratory of Fine Chemicals, Dalian University of Technology

[2] Shandong Collaborative Innovation Center of Eco-Chemical Engineering, College of Chemical Engineering, Qingdao University of Science and Technology

[3] Department of Medical Imaging, Cancer Hospital of China Medical University, Liaoning Cancer Hospital and Institute

[4] Institute of Frontier and Interdisciplinary Science, Shandong University

来源：

Chinese Chemical Letters | 2021年 / 32卷 / 12期

基金：

中央高校基本科研业务费专项资金资助; 中国国家自然科学基金;

关键词：

D O I：

暂无

中图分类号：

TQ421.7 [临床诊断用试剂]; R730.5 [肿瘤治疗学];

学科分类号：

摘要：

A variety of nano-engineered photosensitizers have been developed for photodynamic therapy(PDT)of cancer diseases. However, traditional nano-engineering methods usually cannot avoid drug leakage and premature release, and have disadvantages such as low drug load and inaccurate release.The self-assembly strategy based on amphiphilic peptides has been considered to be more attractive nano-engineering method. Here we developed novel acid-activatable self-assembled nanophotosensitizers based on an amphiphilic peptide derivative. The peptide derivative was synthesized from a fluorescein molecule with thermally activated delayed fluorescence(TADF). The self-assembled nanophotosensitizers can specifically enter the tumor cells and disassemble inside lysosomes companied with “turn-on” fluorescence and photodynamic therapy effect. Such smart nanophotosensitizers will open new opportunities for cancer theranostics.

引用

页码：3903 / 3906

页数：4

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