Two neuropeptides from synganglia of the hard tick, Ixodes sinensis (Acari: Ixodidae)

被引：0
|
作者：
LI Jianxu
Graduate School of the Chinese Academy of Sciences
Shengyang Orthopaedic Hospital
College of Biological Sciences
机构：
来源：
ChineseScienceBulletin | 2006年 / 22期
关键词：
Ixodes sinensis; synganglia; neuropeptide; antinociceptive; relaxant effect;
D O I：
暂无
中图分类号：
R741 [神经病学];
学科分类号：
1002 ;
摘要：
Two neuropeptides were isolated from synganglia (central nervous system) of the hard tick, Ixodes sinensis. Their primary sequences were established as Leu-Val-Val-Tyr-Pro-Trp-Thr-Lys and Trp-Glu-Lys-Leu-Gly-Ser-Met-Glu-Thr-Leu. By hot plate bioassay, neuropeptide a displayed strong antino-ciceptive effect in mice by a dose-dependent behavior, while neuropeptide b had some relaxant effects on the isolated rat strip. These neuropeptides might be involved in down-regulating the host’s defensive reaction.
引用
收藏
页码：2743 / 2747
页数：5
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