Antiviral effect of polyphenol rich plant extracts on herpes simplex virus type 1

被引：0

作者：

Sayed AElToumy ^{[1
]}

Josline YSalib ^{[1
]}

Walaa AElKashak ^{[2
]}

Christel Marty ^{[3
]}

Gilles Bedoux ^{[3
]}

Nathalie Bourgougnon ^{[3
]}

机构：

[1] Chemistry of Tannins Department, National Research Centre

[2] Chemistry of Natural Compounds Department, National Research Centre

[3] Centre de Recherché et d'enseignement Yves Coppens, Campus de Tohannic

来源：

Food Science and Human Wellness | 2018年 / 7卷 / 01期

关键词：

D O I：

暂无

中图分类号：

TQ460.1 [基础理论];

学科分类号：

1007 ;

摘要：

Evaluation of the anti-herpetic activity of 25 Egyptian plants extracts was investigated in vitro in this study. The antiviral activity against Herpes Simplex Virus type 1(HSV-1) was done on Vero cell lines by cell viability. Only two plants extracts; namely Euphorbia coopire(Euphorbiaceae) and Morus alba(Moraceae) showed potent anti-herpetic activity and six other extracts showed moderate inhibition. In contrast, a bioassay monitored phytochemical exploration of these two plants led to the isolation of pure flavonoid compounds. The antiviral activity of the isolated compounds was also examined, among which seven pure compounds namely; 7-galloyl catechin, gallic acid, kaempferol 3-O-β-(6''-O-galloyl)-glucopyranoside,quercetin 3-O-β-(6''-O-galloyl)-glucopyranoside, curcumin, quercetin and kaempferol exhibited significant inhibition.

引用

页码：91 / 101

页数：11

共 35 条

[1] Hydrolyzable Tannins (Chebulagic Acid and Punicalagin) Target Viral Glycoprotein-Glycosaminoglycan Interactions To Inhibit Herpes Simplex Virus 1 Entry and Cell-to-Cell Spread [J].

Lin, Liang-Tzung ;

Chen, Ting-Ying ;

Chung, Chueh-Yao ;

Noyce, Ryan S. ;

Grindley, T. Bruce ;

McCormick, Craig ;

Lin, Ta-Chen ;

Wang, Guey-Horng ;

Lin, Chun-Ching ;

Richardson, Christopher D. .

JOURNAL OF VIROLOGY, 2011, 85 (09) :4386-4398

[2] In vitro antiviral activity from Acanthospermum australe on herpesvirus and poliovirus [J].

Rocha Martins, Lucia Regina ;

Brenzan, Mislaine Adriana ;

Nakamura, Celso Vataru ;

Dias Filho, Benedito Prado ;

Nakamura, Tania Ueda ;

Ranieri Cortez, Lucia Elaine ;

Garcia Cortez, Diogenes Aparicio .

PHARMACEUTICAL BIOLOGY, 2011, 49 (01) :26-31

[3]

Antiviral activity and mode of action of propolis extracts and selected compounds[J] . Schnitzler Paul,Neuner Annett,Nolkemper Silke,Zundel Christine,Nowack Hans,Sensch Karl Heinz,Reichling Jürgen.Phytotherapy research : PTR . 2010 (S1)

[4]

IN VITRO ANTI-HSV-2 ACTIVITY OF ISOQUERCETIN FROM HYPTIS FASCICULATA BENTH[J] . Gomes Michelle M. R.,Cerqueira Débora M.,Falc?o Deborah Q.,Menezes Fábio S.,Wigg Marcia D.,Mendes Gabriella S.,Martins Fernanda O.,Silva Joaquim F. M.,Kuster Ricardo M.,Romanos Maria T.V..VIRUS Reviews & Research . 2008 (1-2)

[5] The high prevalence of herpes simplex virus type 1 DNA in human trigeminal ganglia is not a function of age or gender [J].

Hill, James M. ;

Ball, Melvyn J. ;

Neumann, Donna M. ;

Azcuy, Ann M. ;

Bhattacharjee, Partha S. ;

Bouhanik, Saadallah ;

Clement, Christian ;

Lukiw, Walter J. ;

Foster, Timothy P. ;

Kumar, Manish ;

Kaufman, Herbert E. ;

Thompson, Hilary W. .

JOURNAL OF VIROLOGY, 2008, 82 (16) :8230-8234

[6] Antiviral potentials of medicinal plants [J].

Mukhtar, Muhammad ;

Arshad, Mohammad ;

Ahmad, Mahmood ;

Pomerantz, Roger J. ;

Wigdahl, Brian ;

Parveen, Zahida .

VIRUS RESEARCH, 2008, 131 (02) :111-120

[7] Antiherpetic activities of flavonoids against herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) in vitro [J].

Lyu, SY ;

Rhim, JY ;

Park, WB .

ARCHIVES OF PHARMACAL RESEARCH, 2005, 28 (11) :1293-1301

[8] Extracts and molecules from medicinal plants against herpes simplex viruses [J].

Khan, MTH ;

Ather, A ;

Thompson, KD ;

Gambari, R .

ANTIVIRAL RESEARCH, 2005, 67 (02) :107-119

[9]

Flavonol glycosides from the leaves of Eucommia ulmoides O. with glycation inhibitory activity[J] . Hye Young Kim,Byung Ho Moon,Hak Ju Lee,Don Ha Choi.Journal of Ethnopharmacology . 2004 (2)

[10] Treatment of herpes simplex virus infections [J].

Brady, RC ;

Bernstein, DI .

ANTIVIRAL RESEARCH, 2004, 61 (02) :73-81

← 1 2 3 4 →