POLY(N-VINYLPYRROLIDONE)-MODIFIED SURFACES REPEL PLASMA PROTEIN ADSORPTION

被引：0

作者：

武照强

机构：

[1] CollegeofChemistry,ChemicalEngineeringandMaterialsScience,SoochowUniversity,Soochow,China

来源：

ChineseJournalofPolymerScience | 2012年 / 30卷 / 02期

关键词：

Poly(N-vinylpyrrolidone); Surface modification; Protein adsorption; ATRP; Biocompatibility;

D O I：

暂无

中图分类号：

O631.3 [高聚物的化学性质];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

<正>The present work aimed to study the interaction between plasma proteins and PVP-modified surfaces under more complex protein conditions.In the competitive adsorption of fibrinogen（Fg） and human serum albumin（HSA）,the modified surfaces showed preferential adsorption of HSA.In 100%plasma,the amount of Fg adsorbed onto PVP-modified surfaces was as low as 10 ng/cm2,suggesting the excellent protein resistance properties of the modified surfaces.In addition, immunoblots of proteins eluted from the modified surfaces after plasma contact confirmed that PVP-modified surfaces can repel most plasma proteins,especially proteins that play important roles in the process of blood coagulation.

引用

页码：235 / 241

页数：7

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