Correlation of RUNX3 expression with microvessel density in colorectal adenocarcinoma tissues and clinical significance

被引：0

作者：

Jun Xue ^{[1
]}

Xue-Liang Wu ^{[1
]}

Xian-Tao Huang ^{[1
]}

Ming Qu ^{[1
]}

Fei Guo ^{[1
]}

Guang-Yuan Sun ^{[1
]}

Peng-Cheng Zhang ^{[1
]}

Lei Han ^{[1
]}

Li-Ming Pan ^{[1
]}

机构：

[1] First Affiliated Hospital,Hebei North University

来源：

Asian Pacific Journal of Tropical Medicine | 2017年 / 01期

关键词：

Colorectal neoplasms; RUNX3; Microvessel density; Clinical significance;

D O I：

暂无

中图分类号：

R735.34 [];

学科分类号：

100214 ;

摘要：

Objective: To study the expression of RUNX3 in colorectal adenocarcinoma tissues and its correlation with microvessel density(MVD),and investigate the clinical pathological prognostic significance of RUNX3 and MVD in patients with colorectal cancer,Methods: The expression value of RUNX3 and MVD in 70 specimens’ colorectal adenocarcinoma tissues were detected by immunohistochemistry staining technique,The correlation between their expression and the clinicopathologic features was also investigated,Results: The expression value of RUNX3 and the positive rates of RUNX3 in colorectal adenocarcinoma tissues were 3.25±1.14 and 25.71%(18/70),The expression value of MVD in colorectal adenocarcinoma tissues was 13.14±3.23,Expression of RUNX3 and MVD value were correlated with CEA,serosal invasion,liver metastasis,lymph node metastasis,and TNM stage(P<0.01),The expression value of RUNX3 had negative correlations with that of MVD,Conclusions: The high expression of RUNX3 could inhibit tumor microvascular generation in order to have negative control response on invasion and distant metastasis.

引用

页码：94 / 97

页数：4

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