Synthesis, Relaxivity and Biodistribution of Novel Magnetic Resonance Imaging (MRI) Contrast Agents:Polylysine (Gd-DTPA/DOTA) with Pendent Galactose Moieties as Hepatocyte-targeting Groups

被引：0

作者：

Ren Xi ZHUO

Yan Jun FU and Jun LIAODept of Chemistry Wuhan University Wuhan ^{[430072
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机构：

来源：

Chinese Chemical Letters | 1997年 / 02期

关键词：

Gd-DTPA/DOTA; with Pendent Galactose Moieties as Hepatocyte-targeting Groups; Contrast Agents; Relaxivity and Biodistribution of Novel Magnetic Resonance Imaging; DTPA; DOTA; MRI;

D O I：

暂无

中图分类号：

O631 [高分子物理和高分子物理化学];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

DTPA or DOTA ligand was introduced into the pendent amino groups of polylysine (DP 268) by mono-mixed anhydride of DTPA or DOTA,and then translated with Gd-EDTA. The resultant polymer chelates were further reacted with 6-O-bromoacetyl-D-galactose to give liver-specific contrast agents for magnetic resonance imaging. These new polymer conjugates were characterized by FT-IR, ICP-AES, UV-Vis spectrophotometry and elemental analysis. Their in vitro spin-lattice relaxivity and body distribution in mice were investigated.

引用

页码：157 / 160

页数：4