Separation of mandelic acid and its derivatives with new immobilized cellulose chiral stationary phase

被引：0

作者：

Jie ZHOU ^{[1
]}

Qian LIU ^{[1
]}

Guang-jun FU ^{[1
]}

Zhen-zhong ZHANG ^{[1
]}

机构：

[1] Key Laboratory of State Ministry of Education for Pharmaceutical Technology, School of Pharmacy, Zhengzhou University

来源：

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) | 2013年 / 07期

关键词：

CHIRALPAKIC; Enantiomeric separation; High-performance liquid chromatography (HPLC); Mandelic acid; Derivatives;

D O I：

暂无

中图分类号：

O657.72 [];

学科分类号：

070302 ; 081704 ;

摘要：

A new liquid chromatographic method has been developed for the chiral separation of the enantiomers of mandelic acid and their derivatives 2-chloromandelic acid, 4-hydroxymandelic acid, 4-methoxymandelic acid, and 3,4,5-trismethoxymandelic acid. The enantiomers were separated by a CHIRALPAKIC (250 mm×4.6 mm, 5 μm). Mandelic acid, 4-methoxymandelic acid, and 3,4,5-trismethoxymandelic acid were baseline resolved (resolution factor (RS )=2.21, RS =2.14, and RS =3.70, respectively). In contrast, the enantioselectivities between CHIRALPAKIC and 2-chloromandelic acid and 4-hydroxymandelic acid investigated were low. By comparing the chromatographs of mandelic acid enantiomers and mandelic acid spiked with (R)-mandelic acid, it was determined that the first effluent was (R)-mandelic acid.

引用

页码：615 / 620

页数：6

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