Effect of vitamin E on oxidative stress status in small intestine of diabetic rat

被引：1

作者：

A Shirpoor ^{[1
]}

MH Khadem Ansari ^{[2
]}

S Salami ^{[2
]}

F Ghaderi Pakdel ^{[1
]}

Y Rasmi ^{[2
]}

机构：

[1] Department of Physiology,Faculty of Medicine,Jaddeh Nazloo,Urmia,Iran

[2] Department of Biochemistry,Faculty of Medicine,Jaddeh Nazloo,Urmia,Iran

来源：

World Journal of Gastroenterology | 2007年 / 32期

关键词：

Diabetes mellitus; Small intestine; Rat; Vitamin E; Oxidative stress;

D O I：

暂无

中图分类号：

R587.1 [糖尿病]; R574 [肠疾病];

学科分类号：

1002 ; 100201 ;

摘要：

AIM:To investigate the effect of vitamin E on oxidative stress status in the small intestine of diabetic rats. METHODS:Twenty-four male Wistar rats were randomly divided into three groups:Control (C),non-treated diabetic (NTD) and vitamin E-treated diabetic (VETD) groups. The increases in lipid peroxidation,protein oxidation and superoxide dismutase (SOD) in these three groups was compared after 6 wk. RESULTS:There was no significant difference in catalase activity between NTD and control rats. Compared to NTD rats,the treatment with vitamin E significantly decreased lipid peroxidation and protein oxidation,and also increased catalase activity and SOD. CONCLUSION:The results revealed the occurrence of oxidative stress in the small intestine of diabetic rats. Vitamin E,as an antioxidant,attenuates lipid peroxidation and protein oxidation,and increases antioxidant defense mechanism.

引用

页码：4340 / 4344

页数：5

共 13 条

[1]

Non-antioxidant molecular functions of α-tocopherol （vitamin E）[J] . Angelo Azzi,Roberta Ricciarelli,Jean-Marc Zingg.FEBS Letters . 2002 (1)

[2]

Remodelling of zero-stress state of small intestine in streptozotocin-induced diabetic rats. Effect of gliclazide[J] . J. Zhao,H. Sha,S. Zhou,X. Tong,F.Y. Zhuang,H. Gregersen.Digestive and Liver Disease . 2002 (10)

[3] Surgical stress induces phospholipid degradation in the intestinal brush border membrane [J].

Prabhu, R ;

Anup, R ;

Balasubramanian, KA .

JOURNAL OF SURGICAL RESEARCH, 2000, 94 (02) :178-184

[4] Effects of antioxidant enzymes in the molecular control of reactive oxygen species toxicology [J].

Matés, JM .

BIOGENIC AMINES, 2000, 16 (01) :53-62

[5]

The gastrointestinal tract: A major site of antioxidant action?[J] . Barry Halliwell,Kaicun Zhao,Matthew Whiteman.Free Radical Research . 2000 (6)

[6] Review [J].

Andrew Marshall .

Nature Biotechnology, 2000, 18 (12) :1233-1233

[7] Modulation of hepatic and intestinal Glutathione S-transferases and other antioxidant enzymes by dietary lipids in streptozotocin diabetic rats [J].

Girón, MD ;

Salto, R ;

González, Y ;

Girón, JA ;

Nieto, N ;

Periago, JL ;

Suárez, D ;

Hortelano, P .

CHEMOSPHERE, 1999, 38 (13) :3003-3013

[8]

Comparative study on dynamics of antioxidative action of α-tocopheryl hydroquinone, ubiquinol, and α-tocopherol against lipid peroxidation[J] . Honglian Shi,Noriko Noguchi,Etsuo Niki.Free Radical Biology and Medicine . 1999 (3)

[9]

Lipid peroxidative damage on cadmium exposure and alterations in antioxidantsystem in rat erythrocytes: A study with relation to time[J] . S. Sarkar,P. Yadav,D. Bhatnagar.BioMetals . 1998 (2)

[10]

Protection of vitamin E, selenium, trolox C, ascorbic acid palmitate, acetylcysteine, coenzyme Q 0 , coenzyme Q 10 , beta-carotene, canthaxanthin, and （+）-catechin against oxidative damage to rat blood and tissues in vivo[J] . Hao Chen,Al L. Tappel.Free Radical Biology and Medicine . 1995 (5)

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