Global Positioning System technique is widely used to monitor the deformations of all kinds of buildings and constructions. According to the characteristics of the high precise GPS deformation monitoring, the theory and practice of the SSDM (Similar Single-Difference Methodology) for GPS deformation monitoring are introduced synthetically from the background, the essential mathematic model,the error sources and control measures, the monitoring schemes and the software development. Some arguments are also given in the form of reference literatures. Based on the first pe- riod observation results of the GPS monitor network, SSDM solves the monitoring points′ deformation values at a sin- gle epoch from carrier phases directly, without needing to solve baseline vectors and network adjustment. The SSDM avoids the troublesome problem of detecting and repairing cycle slips, and can be used in static and dynamic deforma- tion monitoring. In the SSDM, the unknown parameters have no relation to the numbers of satellites. If the number of synchronous satellites between stations is not less than two, the monitoring point’s deformation information can be solved easily.